Thursday 16 October, 2025
Objectives: – Understand the differences observed in the pharmacokinetic analysis (steady state and accumulation assessments) of a repeated dose administration…
Read morePoster: Model evaluation
Population Pharmacokinetics of Sumatriptan in Healthy Korean Male Subjects
Thursday 16 October, 2025
Objectives: Sumatriptan, a selective agonist for vascular serotonin (5-HT1) receptor causing vasoconstriction of cerebral arteries is used for the acute…
Read morePopulation pharmacokinetics of S-amlodipine in healthy Korean male subjects
Thursday 16 October, 2025
Objectives: Amlodipine, a third-generation dihydropyridine calcium channel blocker that has been used for hypertension and angina pectoris, is known to…
Read moreAssessment of Mechanism of Action and Drug Effects in Early Signal of Efficacy Trials Using Integrated Glucose-Insulin Modeling: A Simulation-Estimation Approach
Thursday 16 October, 2025
Objectives: An integrated glucose-insulin (IGI) model describing glucose and insulin regulation during oral glucose tolerance tests (OGTT) has been proposed…
Read morePredicting tacrolimus doses early after kidney transplantation – superiority of theory based models
Thursday 16 October, 2025
Objectives: Two independent population pharmacokinetic models have been developed for tacrolimus in kidney transplant recipients in Brisbane [1] and Oslo [2]….
Read moreApplication of the Simcyp PBPK/PD model to Simulate PK and PD of Nifedipine in Japanese Populations
Thursday 16 October, 2025
Objectives: The recent success in application of systems approach in the area of predicting pharmacokinetics (PK) has led many to…
Read moreComparison of Tolerance Models for Neopterin Elevation Following Interferon beta-1a or PEGylated Interferon beta-1a treatment in Rhesus Monkeys
Thursday 16 October, 2025
Objectives: Seven tolerance models were compared to describe neopterin response as a pharmacodynamic marker and to explore the mechanisms of…
Read moreLog likelihood profile intervals for ED50
Thursday 16 October, 2025
Objectives: Wald type of confidence intervals are easily computed but relies on approximately normal distribution of estimators. Log likelihood profile intervals…
Read moreVarious validation methods to check the estimation methods with stochastic sampling approach
Thursday 16 October, 2025
Objectives: In these days, NONMEM provides new estimation methods to estimate population PK/PD model parameters. These new methods – IMP,…
Read morePopulation Pharmacokinetics of QVA149, the fixed dose combination of Indacaterol maleate and Glycopyrronium bromide in Chronic Obstructive Pulmonary Disease (COPD) patients
Thursday 16 October, 2025
Objectives: QVA149 is an inhaled, once-daily, first fixed-dose combination of indacaterol maleate (long-acting β2-agonist) and glycopyrronium bromide (long acting muscarinic…
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