Thursday 16 October, 2025
Objectives: Etoposide is a widely-used anticancer drug in both pediatric and adult oncology. The pharmacokinetics is well characterized with high…
Read morePoster: Methodology- PBPK
Nonlinear Pharmacokinetic Model For Interleukin-12 Gene Therapy
Thursday 16 October, 2025
Objectives: Several animal and human clinical studies have shown the therapeutic potential of interleukin-12 (IL-12) for the treatment of cancer…
Read moreLumping of Physiologically Based Pharmacokinetic Models and a Mechanistic Derivation of Classical Compartmental Models
Thursday 16 October, 2025
Objectives: In drug discovery and development, classical compartment models and physiologically based pharmacokinetic (PBPK) models are successfully used to analyze…
Read morePhysiology-based Simulations of Amikacin Pharmacokinetics in Preterm Neonates
Thursday 16 October, 2025
Objectives: This work aimed to extend the database of the physiology-based pharmacokinetic (PBPK) software PK-Sim® to enable simulations in preterm…
Read moreA novel physiological model to simulate gastrointestinal fluid dynamics, transit of luminal contents, absorption, and pre-systemic metabolism of orally administered drugs in humans
Thursday 16 October, 2025
Objectives: To allow for a precise prediction of oral drug absorption, drug-drug interactions within the gut wall, and the effects…
Read moreA physiology-based pharmacokinetic model describing the disposition of a novel selective anxiolytic drug afobazole and its metabolites in rats.
Thursday 16 October, 2025
Objectives: The purpose of this study was to model the pharmacokinetics of a novel selective anxiolytic drug afobazole [2-(2-morpholinoethylthio)-5-ethoxybenzimidazole dihydrocloride]…
Read moreLink between cyclosporin exposure in tissues and graft versus host disease in paediatric bone marrow transplantation: analysis by a PBPK model
Thursday 16 October, 2025
Objectives: In bone marrow transplantation (BMT), cyclosporin is used to prevent the graft versus host disease (GVHD). A retrospective analysis…
Read moreInfluence of cyclosporin dosing schedule on receptor occupancy in bone marrow transplantation: analysis with a PBPK-PD model
Thursday 16 October, 2025
Objectives: In bone marrow transplantation, cyclosporin is administered to prevent graft-versus-host disease (aGvHD), which occurs mainly in three organs (skin,…
Read moreInfluence of cyclosporin infusion duration on efficacy in paediatric bone marrow transplantation: analysis by a PBPK model
Thursday 16 October, 2025
Objectives: In bone marrow transplantation (BMT), cyclosporin is used to prevent the graft versus host disease (GVHD). In our hospital,…
Read moreWhole-Body Physiologically-Based Pharmacokinetic (WB-PBPK) Modeling of Moxifloxacin (MFX) to Support a Translational Approach in Pediatric Study Design
Thursday 16 October, 2025
Objectives: Pediatric development strategies requested by FDA and EMEA aim for dosing recommendations to maintain efficacy and safety in different…
Read more