Thursday 16 October, 2025
Objective: The utilization of tools for automated model development results in a challenge to re-think and update common workflows and…
Read morePoster: Methodology - Other topics
Overview of Korean Pharmacometrics Modeling Library and web-based pharmacometrics platform
Thursday 16 October, 2025
Objectives: Since, an increasing number of pharmacometrics (PM) models have been developed based on data in Korea, which leads to…
Read moreWeb based platform for clinical pharmacokinetic consultation service (CPCS) with Non-linear Mixed Effect Model
Thursday 16 October, 2025
Objectives: Demand of individualized pharmaceutical intervention is on growing in certain clinical situations, yet majority of existing applications used for…
Read moreContainerized NONMEM and its assistant software in R development environment
Thursday 16 October, 2025
Objectives: Nonlinear mixed effect modeling (NONMEM) for pharmacologic problem is a multidiscipline, highly computer-power demanding and time-spending task, so that…
Read moreApplication of Item Response Theory in Early Phase Clinical Trials: Utilization of a Reference Model to Analyse the Montgomery-Åsberg Depression Rating Scale.
Thursday 16 October, 2025
Objectives: Item response theory (IRT) has shown to be a valuable asset for the analysis of (late phase) clinical trials…
Read moreAutomated Machine Learning Acceleration of Pharmacometrics Models in Pumas with JuliaSim
Thursday 16 October, 2025
Objectives: Quantitative systems pharmacology (QsP) may need to change in order to accommodate machine learning (ML), but ML may need…
Read moreImproving the reproducibility of NONMEM-based pharmacometric analyses
Thursday 16 October, 2025
Introduction/Objectives: Pharmacometric analyses are commonly used to support critical decision. Therefore, a high degree of traceability and reproducibility must be…
Read moreStepwise Covariate Modelling (SCM) versus Full Random Effects Modelling (FREM) for covariate modelling of correlated covariates exemplified with tigecycline and liver function markers
Thursday 16 October, 2025
Objectives: Covariate analysis in small datasets or in datasets with correlated covariates is challenging. This study compared the automated covariate…
Read moreA library of parent-metabolite models for the MonolixSuite
Thursday 16 October, 2025
Objectives: For most drugs, a total or part of a dose undergoes a biotransformation before elimination from the human body. It…
Read moreA methodology to estimate population pharmacokinetic parameters from aggregate concentration-time data and its application to gevokizumab.
Thursday 16 October, 2025
Objectives: The aim of the present study was to develop and assess the performance of a methodology to estimate the…
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