Thursday 16 October, 2025
Objectives: This in silico simulation study aims to develop limited sampling strategies (LSSs) for recombinant factor IX (rFIX) concentrate and to…
Read morePoster: Methodology - Other topics
Quantitative Systems Pharmacology (QSP) tools to aid in model development and communication: Vantage QSP Modeling Tools (VQM-Tools)
Thursday 16 October, 2025
Introduction: Quantitative Systems Pharmacology (QSP) models connect physiological mechanisms at the cellular and organ level, to responses at the patient…
Read morePopulation pharmacokinetics of multiple oral doses of alcohol in humans using blood and breath measures
Thursday 16 October, 2025
Objectives: We conducted a cocktail drug-drug interaction study to evaluate the effect of acute ethanol consumption on the most important drug-metabolising…
Read morePopulation pharmacokinetic meta-analysis of seven antiretroviral drugs
Thursday 16 October, 2025
Objectives: The giant advances in antiretroviral therapy (ART) in the last two decades have transformed HIV infection from a deadly disease…
Read moreIn vitro-in vivo correlation (IVIVC) population modeling for the in silico bioequivalence of a long-acting release formulation of Progesterone.
Thursday 16 October, 2025
Objectives: Health authorities carefully evaluate any change in the batch manufacturing process of a drug before and after regulatory approval. In…
Read moreAccounting for uncertainty in the application of generic PBPK workflow to candidate selection
Thursday 16 October, 2025
Introduction: During drug discovery, a high number of drug candidates are screened for their ADME (absorption, distribution, metabolism and excretion)…
Read moreModel-based informed screening of antimalarial combinations
Thursday 16 October, 2025
Introduction: Malaria is treated with combination therapies in order to minimize resistance. However, resistance is unavoidable and therefore the hunt…
Read moreCorrelation structure of Apolipoprotein A4, C3, E kinetics parameters
Thursday 16 October, 2025
Objectives: Apolipoproteins are a family of proteins attached to the surface of lipoproteins, the particles that facilitate the transportation of…
Read moreMyHealthAvatar platform: matching real life patients with the generated virtual profiles from in silico clinical trials
Thursday 16 October, 2025
Objectives: MyHealthAvatar (MHA) platform aims towards a collaborative partnership among patients and healthcare providers [1]. Nowadays, in silico clinical trials (ISCTs),…
Read moreEfficient identification of the optimal dosing regimen with a nonparametric method
Thursday 16 October, 2025
Objectives: To propose a method for efficient identification of a covariate adjusted dosing regimen in “open loop” situations using a…
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