Thursday 16 October, 2025
Introduction: In 2016, an estimated 216 million cases of malaria occurred worldwide, with an estimated 445 000 deaths. The current…
Read morePoster: Methodology - Other topics
IQnca: An open-source R package for efficient and reproducible non-compartmental analysis in R
Thursday 16 October, 2025
Objectives: Non-compartmental analysis (NCA) is a well-established approach to quickly gain valuable insights into a drug’s pharmacokinetics as well as to…
Read moreDevelopment and validation of open-source pharmacometrics software using an iterative software development life cycle methodology: the pmtables R package for submission-ready table generation.
Thursday 16 October, 2025
Introduction/Objectives: Scientists have a need for standardized, programmatically-generated tables summarizing outputs of modeling and simulation analyses. The objective of this work…
Read moreDrug and target parameters impacting target profiles for mono- and multi-specific NANOBODY® molecules – a model-based sensitivity analysis
Thursday 16 October, 2025
Objectives: NANOBODY® molecules are heavy chain only antibodies with molecular weights of 12-15 kDa, i.e., approximately a 10th of the…
Read moreValidation of non-compartmental analysis (NCA) and bioequivalence results of PKanalix with respect to Phoenix WinNonLin and SAS.
Thursday 16 October, 2025
Objectives: Non-compartmental analysis (NCA) is used at all stages of drug development and is a key method to understand the…
Read moreBayesian individual dynamic predictions via a convenient R function using MonolixSuite
Thursday 16 October, 2025
Objectives: Given an NLME population model, Bayesian individual dynamic prediction can be performed for new patients to predict the future…
Read moreNew library of double absorptions PK models for the MonolixSuite, application to veralipride pharmacokinetics
Thursday 16 October, 2025
Introduction: Multiple peaks in plasma concentration-time curves are quite common, and can be explained by different physiological processes, such as…
Read moreAn R package for Automated Generation of Item Response Theory Model NONMEM Control File
Thursday 16 October, 2025
Introduction Pharmacometrics Item response theory (IRT) models have been recognized as a valuable modeling approach for analyzing healthcare related composite…
Read moreUsing the M3 Method in Exploratory Plots and in NCA
Thursday 16 October, 2025
Objectives: The M3 method is known to NONMEM users as a standard method for handling of below the limit of quantification…
Read moreCampsis: A generic, easy-to-use and intuitive PK/PD simulation platform based on R packages RxODE and mrgsolve
Thursday 16 October, 2025
Introduction: Campsis (www.campsis.org) is an open source PK/PD simulation suite running R, freely available on CRAN [1] and GitHub [2],…
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