Thursday 16 October, 2025
Introduction: Missingness of covariate data is a prevalent challenge in pharmacometrics research [1]. Covariate data may be incomplete under three mechanisms:…
Read morePoster: Methodology - New Modelling Approaches
Development and evaluation of nlmixr2auto: Automated open-source model building
Thursday 16 October, 2025
Introduction/Objectives. Complex pharmacometric model building reduces the time available to focus on interpretation and application of results. Automated modelling leverages…
Read moreIndividualized Prediction of Gentamicin Concentration in Neonates: A Multimodal Approach of PBPK Modeling and Machine Learning
Thursday 16 October, 2025
Objectives: The efficacy of drug therapy in neonates critically depends on selecting appropriate dosage regimens. Physiologically based pharmacokinetic (PBPK) modelling…
Read moreModel-integrated bioequivalence method for highly variable drugs with long half-life: a simulation study comparing complete washout and incomplete washout designs
Thursday 16 October, 2025
Objectives: An in vivo bioequivalence (BE) study with pharmacokinetic (PK) endpoints may be recommended to support the conclusion of therapeutic…
Read moreA Two-Stages Global Sensitivity Analysis in presence of correlated inputs: Application on a Tumor-in-host-growth Inhibition model based on the Dynamic Energy Budget theory
Thursday 16 October, 2025
Objectives: Global sensitivity analysis (GSA) aims to evaluate the impact of variability and/or uncertainty of the model input parameters on…
Read moreTowards PBPK model development for oral absorption in PhysPK
Thursday 16 October, 2025
Objectives: Oral drug absorption is a complex process dependent on the interplay between processes depending on both compound and dynamic…
Read moreAutomatic Development of Pharmacokinetic Structural Models – Pharmpy Model Search Tool
Thursday 16 October, 2025
Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed. Such…
Read morePopulation-level treatment optimization using a multi-objective optimization strategy
Thursday 16 October, 2025
Objectives: Optimizing the design of drug treatment schedules can be complex process as it may requires simultaneous consideration of multiple…
Read moreLithium pharmacometrics: review of population pharmacokinetics models, external evaluation using non compartmental literature data and model’s updating based on straightforward integration of glomerular filtration rate.
Thursday 16 October, 2025
Introduction: Lithium is recommended in the treatment of bipolar disorder and displays a narrow therapeutic range. Thus, treatment optimization through…
Read moreDeepPumas for automatic discovery of individualizable functions governing longitudinal patient outcomes
Thursday 16 October, 2025
Objectives: The recent advent of Scientific Machine Learning (SciML) that enables us to combine the wealth of knowledge that modelers,…
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