Thursday 16 October, 2025
Introduction/Objectives: Quantitative Systems Pharmacology (QSP) models aim at offering a detailed mechanistic understanding of the biological processes underlying health, disease…
Read morePoster: Methodology - New Modelling Approaches
Incorporating complex drug PK with multiple binding targets into a QSP model to predict combined PD effects
Thursday 16 October, 2025
Objectives: More antibody drugs are being made in di- and trimer forms to bind multiple targets in a pathway or…
Read moreStructural model development with compartmental pharmacokinetic models for a range of small molecule subcutaneous data
Thursday 16 October, 2025
Objectives: The development of pharmacokinetic (PK) and pharmacodynamic (PD) models demands considerable time from highly skilled scientists, and the need for…
Read moreA modelling framework for in vitro/in vivo translation of PROTACs PK/PD and PK/Efficacy: accelerating drug discovery of targeted protein degraders
Thursday 16 October, 2025
Objectives: PROTACs [1] are novel small molecules which violate not only the optimal, well-understood physicochemical design space [2], but also…
Read moreAn integrated modelling approach for targeted degradation: insights on optimisation, data requirements and PKPD predictions from semi- or fully-mechanistic models and exact steady state solutions
Thursday 16 October, 2025
Objectives: This work proposes a novel pragmatic modelling approach for targeted protein degradation which captures the essence of the mechanism…
Read morePopulation pharmacokinetic modelling for vancomycin using Bayesian model averaging approach
Thursday 16 October, 2025
Introduction: Vancomycin has been used as a first-line standard treatment against methicillin-resistant Staphylococcus aureus for over 60 years [1]. More…
Read moreComparative Study of Target Mediated Drug Disposition Approximation Methods Based on Validity Conditions: Application to Clinical Trial Studies
Thursday 16 October, 2025
Objectives: Target-Mediated Drug Disposition (TMDD) is a phenomenon that occurs when a potent and specific drug binds to the target site…
Read moreNon-linear autoregressive exogenous modelling to predict individual haematotoxicity during chemotherapy
Thursday 16 October, 2025
Objectives: Cytotoxic cancer therapies frequently result in severe haematotoxic side-effects. Predicting a patient’s haematologic response to treatment is of high…
Read moreCombining biological knowledge and machine learning for predicting dynamics of haematotoxcity after chemotherapy: a comparative analysis
Thursday 16 October, 2025
Objectives: Cytotoxic treatment in cancer therapy is frequently accompanied by dose-limiting haematotoxic side-effects. Predicting an individual’s risk holds significant clinical…
Read morePredicting Motor function scores using uHex4 biomarker effect in Pompe disease
Thursday 16 October, 2025
Objectives: Text regarding objectives. Methods: Text regarding methods. Results: Text regarding results. Conclusions: Text regarding conclusions. References: [1] Text for…
Read more