Thursday 16 October, 2025
Introduction: Exposure-response relations for time to event data are often analyzed with non-parametric (Kaplan Meier) or semi-parametric (Cox regression) methods….
Read morePoster: Methodology - New Modelling Approaches
Model-informed artificial intelligence (AI) solution enabling real-time predictions: towards next generation modeling
Thursday 16 October, 2025
Introduction/Objectives: The introduction of nonlinear mixed-effects modeling has led to a revolution in the analysis of pharmacokinetic (PK) and pharmacodynamic…
Read moreAssessing treatment failure under combination therapy in HIV disease
Thursday 16 October, 2025
Objectives: The emergence of drug-resistant mutants remains a challenge to successful anti-human immunodeficiency virus (HIV) therapy [1]. Upon treatment failure, the…
Read moreExploring Inter-study variability in the context of modeling unperturbed xenograft data
Thursday 16 October, 2025
Objectives: Pharmacokinetic/Pharmacodynamic characterization of anti-tumor drug effects using xenograft studies [1] is an important process during early stages of oncology drug…
Read moreSemi-mechanistic Pharmacodynamic model of complex receptor-hormone dynamics
Thursday 16 October, 2025
Objectives: The objective of this work is to develop a pharmacodynamic model describing hormone time-course after the administration of a…
Read moreModel Averaging and Selection methods for model structure and parameter uncertainty quantification
Thursday 16 October, 2025
Objectives: There have been several attempts through model averaging and model selection to weaken the assumptions around model structure by pre-specifying multiple…
Read moreMulti-Endpoint Item-Response Modelling for Integrating Several Endpoints in Alzheimer’s Disease Drug Trials
Thursday 16 October, 2025
Objectives: Several rating scales are used in Alzheimer’s Disease (AD) to describe the heterogeneity of the disorder as a collection of…
Read moreEstimation of population parameter values and variability coupling non-linear mixed-effects modeling (based on SAEM algorithm) with a whole-body PBPK model
Thursday 16 October, 2025
Introduction: Physiologically Based Pharmacokinetic (PBPK) modelling is a powerful tool in drug development since it allows the integration of drug specific…
Read moreAnalysing the contribution to receptor occupancy from active metabolites
Thursday 16 October, 2025
Objectives: To present a study design and modelling approach for investigating the contribution to receptor occupancy from active metabolites with longer…
Read moreTobramycin dose individualization using the MonolixSuite
Thursday 16 October, 2025
Objectives: The concept of personalized medicine has long been promoted to bring more benefits to patients, in particular by adapting the…
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