Thursday 16 October, 2025
Objectives: In silico experiments and simulations using physiologically based pharmacokinetic (PBPK) and allometric approaches have played an important role in pharmaceutical…
Read morePoster: Methodology - New Modelling Approaches
Identifiability in nonlinear mixed effect models: the example of in vitro erythropoiesis
Thursday 16 October, 2025
Introduction: Mounting evidence demonstrates the importance of heterogeneity in biological processes. This increasing awareness has accompanied the development of Nonlinear…
Read moreWhy patients may not benefit from effective oncology drugs
Thursday 16 October, 2025
Objectives: To show that patients may not always benefit from an effective treatment through competing risks analysis of simulated data….
Read moreCovariate effects on competing events: a simulation study comparing approaches
Thursday 16 October, 2025
Objectives: To compare the performance of various analysis methods to detect covariate effects on competing events. To explore the influence…
Read morenlmixr2, rxode2 and Monolix: interchangeable models using monolix2rx and babelmixr2
Thursday 16 October, 2025
Introduction: nlmixr2 (www.nlmixr2.org) is an open-source R package, freely available on CRAN[1] and GitHub[2]. It builds on rxode2[3], an R package for…
Read moreUse of mixture models in pharmacometric model-based analysis of confirmatory trials: part II – control of the type I error with real placebo data
Thursday 16 October, 2025
Objectives Controlling the type I error of the clinical trials designed to evidence drug efficacy is critical during drug development,…
Read moreComparison of seven NLMEM approaches to test for drug effect using real placebo data
Thursday 16 October, 2025
Background Model averaging across drug models[1] (MAD), individual model averaging[2] (IMA) and corrected LRT[3] (cLRT) has shown to have a…
Read moreA Semi-mechanistic population pharmacokinetic model quantifying hair concentrations of ritonavir-boosted atazanavir. A study of HIV infected Zimbabweans adolescents.
Thursday 16 October, 2025
Introduction: An estimated 36.9 million people were living with Human Immunodeficiency Virus (HIV) worldwide in 2017. Of these approximately 3.0…
Read moreReducing QSP models to derive mechanism-based PD models: warfarin-INR as an example
Thursday 16 October, 2025
Objectives: Quantitative systems pharmacology (QSP) models integrate comprehensive knowledge about pharmacologically relevant processes. QSP models, however, are usually very complex…
Read moreAn integrated pharmacometric dialysis model to evaluate the pharmacokinetic impact of renal replacement therapy
Thursday 16 October, 2025
Objectives: Renal replacement therapy (RRT) may alter the pharmacokinetic (PK) profile. Information on the impact of RRT on the PK…
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