Thursday 16 October, 2025
Introduction: Evaluation of novel therapies or interventions for regulatory approval depends on the measurement of clinically relevant and often semi-quantitative…
Read morePoster: Methodology - New Modelling Approaches
Quantification of model misspecification of population pharmacokinetic models by a machine learning postprocessing correction of the residual variability
Thursday 16 October, 2025
Objectives: In Population Pharmacokinetics (PopPK) residual unexplained variability (RUV) characterizes the remaining observed variability having taken into account the variability…
Read moreRe-writing oral pharmacokinetics using physiologically based finite time pharmacokinetic (PBFTPK) models
Thursday 16 October, 2025
Objectives: The development of the Finite Absorption Time (FAT) concept for oral drug absorption was accomplished recently(1-4). These studies demonstrate…
Read moreFractal kinetic implementation in population modeling
Thursday 16 October, 2025
Objectives: Compartment modeling is a widely accepted technique in the field of pharmacokinetic analysis. However, conventional compartment modeling is commonly…
Read moreRobust Parameter Estimation of Rational Ordinary Differential Equations for NLME and QSP
Thursday 16 October, 2025
Introduction/Objectives: Parameter estimation of ordinary differential equation (ODE) models is the essential step of many inference methods in nonlinear mixed…
Read moreUncertainty quantified discovery of chemical reaction systems via Bayesian scientific machine learning
Thursday 16 October, 2025
Objectives: Mechanistic models in quantitative systems pharmacology (QSP) offer more interpretability than purely data-driven machine learning approaches, but practitioners often…
Read moreMathematical modeling of autoimmune diseases: a systematic review and analysis for advancing therapeutic development
Thursday 16 October, 2025
Introduction: The intricate pathogenesis and etiology of autoimmune diseases (ADs) pose challenges to the research and development of novel therapeutic…
Read moreBelimumab Pharmacokinetic Simulations to Select an Appropriate Subcutaneous Dosing Regimen to Treat Paediatric Patients with Active Lupus Nephritis
Thursday 16 October, 2025
Introduction: The cytokine B-cell lymphocyte stimulating protein (BLyS) plays an important role in the production and differentiation of B cells…
Read moreA mechanism-based pharmacokinetic/pharmacodynamic model to evaluate the mutual relationships between YH4808, a novel K+-competitive acid blocker, and intragastric pH in humans
Thursday 16 October, 2025
Introduction: YH4808 is a highly potent, selective and reversible potassium-competitive acid blocker of the H+/K+-ATPase under development to treat gastric acid-related…
Read moreTowards personalised medicine in Non-Small Cell Lung Cancer: design of a forecasting model of disease-progression to overall survival.
Thursday 16 October, 2025
Objectives: Lung cancer is the second most common cancer and the leading cause of cancer related death worldwide. In the…
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