Thursday 7 May, 2026
Introduction: Model evaluation in pharmacometrics relies on multiple criteria, including likelihood-based statistics, parameter precision, plausibility of covariate effects, and graphical…
Read morePoster: Methodology - Model Evaluation
BAYESIAN QUANTIFICATION OF BIAS AND UNCERTAINTY IN SIMCYP V19 PREDICTIONS OF DRUG-DRUG INTERACTIONS
Thursday 7 May, 2026
As part of the qualification of the Simcyp Simulator V19 by the European Medicine Agency (EMA) in 2025, a statistical…
Read moreSensitivity analysis and calibration for a computationally expensive PBPK model: a case study for the PERSERIS™ in-situ forming PLGA-based implant
Thursday 7 May, 2026
Introduction: Sensitivity Analysis (SA) describes a class of methods for studying the relationships between the inputs and outputs of a…
Read moreCross-tissue evaluation of a proteomics-derived ppm-to-nM conversion for target expression inputs to antibody PBPK/TMDD models
Thursday 7 May, 2026
Introduction: In antibody therapy, accurate prediction of first-in-human dose often requires accounting for target-mediated drug disposition (TMDD), for which PBPK…
Read morePredicting Receptor Occupancy via Empirical Approximations from Nonlinear Population PK Modeling
Thursday 7 May, 2026
Objectives Assessing monoclonal antibody target engagement in vivo is critical to understanding drug activity and informing the selection of a…
Read moreRE-ESTIMATION OF PEDIATRIC POPULATION PHARMACOKINETIC MODELS OF DOLUTEGRAVIR IN A CANADIAN POPULATION UNDERGOING THERAPEUTIC DRUG MONITORING
Thursday 7 May, 2026
Introduction: Dolutegravir (DTG) is a widely used integrase inhibitor for HIV treatment [1]. Despite its favorable pharmacokinetic profile, interindividual variability…
Read moreVisual Predictive Checks for Real-World Data using Propensity-Score-Matching
Thursday 7 May, 2026
Background: It is known that visual predictive checks (VPC) cannot be used reliably when real world data (RWD) or data…
Read moreASSESSMENT OF EXPOSURE-RESPONSE CAUSALITY AND HOMOGENEITY VIA PARTITIONED EFFECTS MODELING AND MEDIATION ANALYSIS: A MOXONIDINE CASE STUDY
Thursday 7 May, 2026
Objectives Causality and homogeneity in exposure–response (E-R) analyses can be assessed by the partitioned effects (PE) model, based on an…
Read moreReference-Corrected VPCs: Addressing Model Evaluation Challenges with Real-World Data and Adaptive Designs
Thursday 7 May, 2026
Background The visual predictive check (VPC) and the prediction-corrected VPC (pcVPC) are standard diagnostic tools used to evaluate the suitability…
Read moreEvaluating the utility of dose/exposure-response modeling for dose optimization in oncology
Thursday 16 October, 2025
Introduction: Conventionally, single arm dose-expansion trials were widely used to select the therapeutic dose for oncology. Many gaps in the conventional…
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