Thursday 16 October, 2025
Objectives: The ability to quickly and easily simulate clinical trial scenarios is essential in drug development [1]. However, despite the…
Read morePoster: Methodology- Design
Comparison of Different Global Optimal Design Approximations
Thursday 16 October, 2025
Objectives:To compare Monte-Carlo integration and Laplace integral approximation for global optimal design in terms of precision, runtime and best study…
Read moreOptimisation of experimental design for drug screening in behavioural models of pain.
Thursday 16 October, 2025
Objectives: Recently, an optimal design technique was developed for the analysis of discrete variables[1]. We aimed to evaluate the feasibility…
Read moreComparative analysis of scaling methods for dose selection in paediatric indications
Thursday 16 October, 2025
Objectives: Dose selection for paediatric indications remains a major challenge in early clinical development. Despite understanding of the role of…
Read moreDesign evaluation and optimisation in crossover pharmacokinetic studies analyzed by nonlinear mixed effects models
Thursday 16 October, 2025
Objectives: Nonlinear mixed effects models (NLMEM) can be used to analyze crossover pharmacokinetic (PK) bioequivalence trials. Before modelling, it is…
Read moreApplication of a semi-physiological model describing time-varying pharmacokinetics to support optimal clinical study design
Thursday 16 October, 2025
Introduction: Physiological changes during pregnancy can alter drug pharmacokinetics1 (PK). Precise quantification of PK changes during pregnancy is therefore required…
Read moreGeneralisation of T-optimality for discriminating between competing models – an application to paracetamol overdose
Thursday 16 October, 2025
Background and Objectives: The T-optimality criterion for model discrimination were introduced by Atkinson and Fedorov [1]. Application of this method…
Read moreEstimation of Population Pharmacokinetic Measures and Selection of Sampling Times
Thursday 16 October, 2025
Objectives: In many pharmaceutical studies multiple blood samples are taken for each enrolled patient, and various population pharmacokinetic (PK) measures,…
Read moreOptimization of sampling times for PK/PD models: approximation of elemental Fisher information matrix
Thursday 16 October, 2025
Introduction: Optimal design of population PK and PD studies has seen an increasing interest over the last decade. In 2006,…
Read moreOptimal window design of blood pressure time measurements in hypertensive dippers and non-dippers using ABPM: Application of the compound D-optimality approach.
Thursday 16 October, 2025
Objectives: Ambulatory Blood Pressure Monitoring (ABPM) is a non invasive method whose both diagnostic value and prognostic significance have been…
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