Thursday 16 October, 2025
Background: NONMEM is the most widely used software for population PKPD analyses. The latest version, NONMEM 7 (NM7), includes several…
Read morePoster: Methodology- Algorithms
Comprehensive Virtual Patient Platform Implemented For Anti-Angiogentic Drugs Development
Thursday 16 October, 2025
Background: Over the past decades biomathematical model have evolved and their usage in actual clinical research is growing. Together with…
Read moreNew Estimation Methods in NONMEM 7: Evaluation of Bias and Precision
Thursday 16 October, 2025
Objectives: The aim was to investigate the performance with respect to bias and precision of all estimation methods available in…
Read moreHierarchical-likelihood approach for nonlinear mixed-effect models
Thursday 16 October, 2025
Objectives: Nonlinear mixed effect models have been widely used for the analysis of pharmacokinetic data. These models frequently lead to…
Read moreImproved parameter estimation and design optimization for In Vitro ligand binding experiments
Thursday 16 October, 2025
Objectives: Previous analyses have demonstrated that simultaneous non-linear regression (SNLR) versus sequential non-linear regression (NLR) provided better approximation to the…
Read moreNonparametric Approach using Gaussian Kernels Estimates Multivariate Probability Densities in Population Pharmacokinetics
Thursday 16 October, 2025
Objectives: Describe the interindividual variability (interIV) by means of a multivariate probability density function (pdf) using a two-stage nonparametric procedure. Our…
Read moreExtension of the SAEM algorithm and evaluation of Wald and likelihood ratio tests for interaction or bioequivalence studies
Thursday 16 October, 2025
Objectives: The context of our work is the analysis of pharmacokinetic (PK) crossover trials using nonlinear mixed effects model (NLMEM)…
Read moreAutomatic Selection of Optimal Configuration of Artificial Neural Networks
Thursday 16 October, 2025
Objectives: A novel mixed-integer nonlinear programming (MINLP) based mathematical formulation for artificial neural network (ANN) analysis which minimises the complexity…
Read moreInitial Estimates for Parameter Estimation
Thursday 16 October, 2025
Objectives: Parameter estimation for models involving differential equations corresponds to a dynamic optimization problem, which in general has multiple locally…
Read moreAccelerating the Rate of Adoption of New Pharmacometrics Platforms Using Formal Tools For Model Interconversion
Thursday 16 October, 2025
Objectives: The FDA can accelerate the rate of approval of new drugs by accelerating the rate of adoption in industry…
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