Thursday 16 October, 2025
Objectives: 22E9 is a monoclonal antibody that binds to the pro-inflammatory cytokine granulocyte macrophage colony-stimulating factor (GM-CSF), thereby neutralizing its…
Read morePoster: Inflammation
Population PKPD modeling of dose-response and time course of peripheral lymphocytes after single and repeated administration of the S1P1/5 modulator, BAF312, in healthy volunteers.
Thursday 16 October, 2025
Objectives: BAF312 is a next generation S1P receptor modulator, selectively targeting S1P1 and S1P5. The drug reduces the peripheral blood lymphocytes count…
Read moreModel based approach to inform early clinical development for a biologic
Thursday 16 October, 2025
Objectives: The knowledge from preclinical in vitro and in vivo preclinical models was integrated in a model-based approach in order…
Read moreMechanistic Modeling of the Link between Interleukin 6 Receptor Blockade with Tocilizumab and Its Hematological Effects
Thursday 16 October, 2025
Objectives: Tocilizumab (TZ) is a recombinant humanized IL-6 receptor monoclonal antibody that inhibits binding of IL-6 to its soluble (sIL-6R)…
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