Thursday 16 October, 2025
Objectives: Although observations of time-variant changes in the renin cascade are available in dogs, no detailed chronobiological investigation has been…
Read morePoster: Endocrine
PKPD modelling of drug induced changes in thyroxine turnover in rat
Thursday 16 October, 2025
Objectives: To determine the in vivo potency of drug induced reduction in plasma thyroxine, T4, levels for three different drugs…
Read moreUsing allometric scaling on an integrated glucose insulin model for humans to investigate anti-diabetics drug effects in rats.
Thursday 16 October, 2025
Objectives: The aim of this project was to allometrically down-scale an integrated glucose insulin (IGI) model, developed on clinical data…
Read moreModelling of glucose absorption
Thursday 16 October, 2025
Objectives: The ingestion of glucose is an extensively studied process. However, few publications describe this process using a population approach and…
Read moreUsing nonlinear mixed effects modeling to characterize the pharmacokinetics and pharmacodynamics of benazepril in dogs.
Thursday 16 October, 2025
Objectives: In the management of canine heart failure, angiotensin converting enzyme inhibitors (ACEIs) e.g. benazepril are the foremost therapeutic option…
Read moreA Quantitative Systems Pharmacology Model Provides Insights into Phosphate Homoeostasis through Multiple Interacting Pathways
Thursday 16 October, 2025
Objectives: Phosphate is an important mineral required for numerous cellular functions such as DNA and membrane lipid synthesis, generation of…
Read moreMechanistic modeling approach relating human gut microbial community to physiologically-relevant biomarkers
Thursday 16 October, 2025
Objectives: The adult human gut houses a microbial community which contains a large number of bacterial species. It is well-known now…
Read moreSemi-mechanistic PK/PD Model of the Effect of Odanacatib, a Cathepsin K Inhibitor, on Bone Turnover to Characterize Lumbar Spine and Distal Forearm Bone Mineral Density in A Phase IIb Study of Postmenopausal Women
Thursday 16 October, 2025
Objectives: Odanacatib (ODN, MK-0822), a potent oral inhibitor of cathepsin K, is being developed to treat osteoporosis. A semi-mechanistic model…
Read moreIntegrated model of glucose homeostasis including the effect of exogenous insulin
Thursday 16 October, 2025
Objectives: Insulin therapy for diabetes patients is designed to mimic the endogenous insulin response of non-diabetic subjects and thereby generate…
Read morePharmacokinetics of concentrated insulin mixtures: a biosimulation approach
Thursday 16 October, 2025
Objectives: Mixtures of soluble and crystalline insulin aspart are currently used in formulated concentrations of 100 U/mL. The purpose of…
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