Thursday 16 October, 2025
Objectives: Paediatric heart failure is rare (1-8/100’000), but it represents a relevant health burden. Current therapy is unsatisfactory, with 5-year…
Read morePoster: Drug/Disease Modelling - Paediatrics
population pharmacokinetics and dose rationale for deferasirox in the treatment of iron overload in paediatric patients undergoing hematopoietic stem cell transplantation
Thursday 16 October, 2025
Introduction: Iron overload (IO) is common in adults and children with malignancies undergoing allogeneic haematopoietic stem cell transplantation (aHSCT) due…
Read moreExternal Validation of a Population Pharmacokinetic Model for Morphine and its Metabolites in Children under 3 Years who Underwent Cardiothoracic Surgery
Thursday 16 October, 2025
Objectives: Morphine is widely used for postoperative pain management in children. Previously, a model was developed by Valkenburg et al….
Read moreAntidepressants transplacental transfer modeling using ex vivo perfusion of isolated human placenta cotyledon
Thursday 16 October, 2025
Introduction: Depression is common in pregnant women [1]. Perinatal depression affects around 6-12% of pregnant women at different trimesters [2-3]….
Read morePredicting the effect of postpartum changes in breastmilk composition on the partitioning of anti-malarial medications
Thursday 16 October, 2025
Introduction: Breastmilk provides the optimum nutrition and immune protection for infants and the World Health Organisation therefore recommends exclusive breastfeeding…
Read morePopulation Pharmacokinetic of ketamine and norketamine in pediatric subjects during analgosedation
Thursday 16 October, 2025
Objectives: Ketamine (KET) is a potent agent for pediatric procedural sedation and anesthesia. Yet ketamine is burdened by adverse events (ADEs),…
Read morePopulation pharmacokinetics of teicoplanin in critically ill children undergoing continuous kindey replacement therapy
Thursday 16 October, 2025
Introduction: Pediatric patients undergoing continuous kidney replacement therapy (CKRT) in intensive care units (ICUs) may suffer from infections caused by…
Read moreCharacterization of the population dose-exposure-efficacy relationships of vamorolone, a synthetic corticosteroid drug in the treatment of Duchenne Muscular Dystrophy (DMD)
Thursday 16 October, 2025
Objectives: Vamorolone (Agamree) is a synthetic steroidal drug approved for the treatment of Duchenne Muscular Dystrophy (DMD), a life-threatening genetic…
Read moreOral amoxicillin/clavulanate in paediatric patients with severe community acquired pneumonia: a popPK analysis from the PediCAP trial
Thursday 16 October, 2025
Objectives: Amoxicillin alone or in combination with clavulanate (co-amoxiclav) is a widely prescribed antibiotic in paediatric infectious disease [1]. Its…
Read morePopulation pharmacokinetic analysis for pediatric patients with inflammatory bowel disease receiving infliximab
Thursday 16 October, 2025
Objectives: Inflammatory bowel disease (IBD) represents chronic inflammatory disorders affecting the gastrointestinal tract, including Crohn’s disease (CD) and ulcerative colitis…
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