Thursday 16 October, 2025
Objectives: While integrase inhibitors have become first line antiretroviral therapy for non-pregnant adults [1], there have been few studies supporting…
Read morePoster: Drug/Disease Modelling - Other Topics
Population pharmacokinetics of cobicistat in once and twice daily regimens in various populations
Thursday 16 October, 2025
Objectives: Cobicistat (COBI) is a selective, mechanism-based inhibitor of the cytochrome P450 (CYP) 3A-enzyme.(1) COBI is approved for pharmacokinetic (PK)…
Read moreComparison of oxazolidinones’ exposure-response for the treatment of tuberculosis
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) is one of the world’s deadliest infectious diseases, causing 1.3 million deaths in 2022. Treatment success rates are…
Read moreDose rationale and metrics of target exposure for tacrolimus and mycophenolate in paediatric patients undergoing solid organ transplantation
Thursday 16 October, 2025
Introduction: Tacrolimus (TAC) is an immunosuppressant prescribed often in combination with mycophenolic acid to patients who undergo organ transplantation. TAC exerts…
Read moreLeveraging in vitro data from novel drug candidates to prioritize antibody combinations in autoimmune disease using a QSP model of IBD
Thursday 16 October, 2025
Objectives: For many autoimmune indications the treatment response has reached a ceiling effect and so novel combination treatment approaches may…
Read moreTowards an integrated mPBPK/PD model for drug-optimization and prediction of relapse after treatment of tuberculosis in mice
Thursday 16 October, 2025
Objectives: The treatment of tuberculosis (TB), one of the most harmful infectious diseases killing millions of people worldwide [1], still…
Read moreIn-silico clinical trials in virtual asthma patients powered by QSP accelerated the development of lunsekimig
Thursday 16 October, 2025
Introduction: Asthma is a heterogenous disease that affects millions of people worldwide. Despite the availability of multiple treatment options, a significant…
Read morePopulation pharmacokinetic modelling of whole blood and intracellular tacrolimus in adult kidney transplanted patients
Thursday 16 October, 2025
Introduction: Tacrolimus is an immunosuppressive drug used to prevent organ rejection in kidney transplanted patients. It has a narrow therapeutic…
Read moreSevoflurane Pharmacokinetics and Pharmacodynamics in Adults During General Anaesthesia
Thursday 16 October, 2025
Background Sevoflurane vapour is inhaled for the induction and maintenance of general anaesthesia. Sevoflurane vapour concentration is measured in real-time…
Read morePopulation pharmacokinetic Models of regular SC insulin for hyperglycemia following acute ischemic stroke among patients with and without pre-existing diabetes mellitus
Thursday 16 October, 2025
Introduction/Objectives: Regardless of pre-stroke diabetes status, patients admitted to the hospital for acute ischemic stroke (AIS) are frequently observed to…
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