Thursday 16 October, 2025
Objectives: Radioligand therapy with Lutetium-177 Prostate Specific Membrane Antigen (177Lu-PSMA) has showed its favorable therapeutic effect in metastatic prostate cancer…
Read morePoster: Drug/Disease Modelling - Oncology
The impact of weekend dosing holidays on the evaluation of the sterilizing efficacy of different 4-drug combinations in a relapsing mouse model of Mycobacterium tuberculosis infection using a logistic Emax model
Thursday 16 October, 2025
Introduction/Objectives: Tuberculosis (TB) remains a leading infectious disease-related cause of death worldwide. Current treatment options are extremely long and complex,…
Read morerhIL-7-hyFc dose optimization for chemotherapy-induced lymphopenia using FcRn mediated IgG disposition model
Thursday 16 October, 2025
Objectives: The rhIL-7-hyFc (hybrid Fc-fused recombinant human interleukin-7; efineptakin alfa) is a homodimeric interleukin-7 (IL-7) fused to the hybrid Fc…
Read morePopulation Pharmacokinetic-Pharmacogenetic Analysis of Osimertinib in patients with Non-Small Cell Lung Cancer
Thursday 16 October, 2025
Objectives: Osimertinib is an oral third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved for the treatment of metastatic…
Read moreDevelopment of a time dependent clearance model for busulfan in paediatric patients to investigate dosing adjustment scenarios
Thursday 16 October, 2025
Introduction: Busulfan is a chemotherapy drug used in haematopoietic stem cell transplantation. While several studies have observed a reduction in…
Read moreThe Markov chain survival modeling platform for cancer burden assessment
Thursday 16 October, 2025
Introduction: The socio-economic impact of cancer remains considerable and is poorly understood. It is associated with higher morbidity and mortality and…
Read moreA comparison of ordinary differential equation and agent-based approaches to PKPD modelling in oncology
Thursday 16 October, 2025
Introduction Mathematical models in oncology aid in the design of drugs and understanding of their mechanisms of action by simulation…
Read moreApplication of an immune-oncology framework to explore the role of regulatory T cells in antitumor response.
Thursday 16 October, 2025
Introduction and Objective: Regulatory T cell (Treg), characterized by the expression of Foxp3 intracellularly and CD25 at the surface, is…
Read moreRelationship between tumor growth and Treg activation status to optimize a previously published Immune oncology framework
Thursday 16 October, 2025
Introduction: The majority of the tumor growth inhibition models described inliterature evaluate the interplay between three major components: the growth…
Read moreQuantification of the difference in oral docetaxel pharmacokinetics in patients with prostate cancer compared to patients with other solid tumours
Thursday 16 October, 2025
Introduction: Oral docetaxel in combination with ritonavir boosting has been investigated for the treatment of solid tumours including prostate cancer…
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