Thursday 7 May, 2026
Introduction: Ventilator-associated pneumonia (VAP) and hospital-acquired pneumonia (HAP) are serious infectious complications in hospitalized and critically ill patients, contributing to…
Read morePoster: Drug/Disease Modelling - Infection
POPULATION PHARMACOKINETICS, ANTIDRUG ANTIBODIES AND EXPOSURE–RESPONSE OF LOTIVIBART (LVB, VH3810109, N6LS) IN VIROLOGICALLY SUPPRESSED ADULTS LIVING WITH HIV FROM THE PHASE 2B EMBRACE STUDY
Thursday 7 May, 2026
Introduction: Lotivibart (LVB, VH3810109, N6LS) is a broadly neutralizing antibody targeting the CD4-binding site of the HIV-1 envelope, currently being…
Read moreINTER-LABORATORY EFFECTS ON PK/PD RELATIONSHIPS IN THE STANDARDIZED COMBINE PNEUMONIA MODEL
Thursday 7 May, 2026
Objectives: The COMBINE consortium has developed a standardized murine pneumonia model to harmonize preclinical efficacy data and improve translational relevance…
Read morePopulation pharmacokinetic modelling of plasma and target-site metronidazole: Reduced target-site exposure suggests underdosing in obese patients
Thursday 7 May, 2026
Introduction: To prevent surgical site infections (SSI) caused by anaerobic bacteria, thus optimising perioperative care, a flat dose of 500…
Read moreThe analysis of a large dataset of PCR-test results in the community reveals the impact of age, variants and vaccination status on SARS-CoV-2 viral dynamics
Thursday 7 May, 2026
Introduction During the COVID-19 pandemic, the emergence of SARS-CoV-2 variants of concern and the rollout of mass vaccination campaigns have…
Read moreTime-varying covariates to enhance mechanistic understanding of antibiotic-induced bacterial morphology changes
Thursday 7 May, 2026
Introduction/Objectives: Carbapenem-resistant Gram-negative bacteria are becoming increasingly prevalent worldwide [1]. Improved understanding of the mechanisms of bacterial killing could potentially…
Read moreQuantifying host and vaccination determinants of viral dynamics in respiratory infections using community-based PCR data
Thursday 7 May, 2026
Introduction: Influenza viruses, respiratory syncytial virus (RSV), and SARS-CoV-2 drive recurrent seasonal epidemics and impose a substantial healthcare burden[1–3]. Since…
Read morePOPULATION PHARMACOKINETIC MODEL OF EXTENDED-RELEASE METFORMIN IN OBESE SOUTH AFRICAN WOMEN WITH HIV RECEIVING DOLUTEGRAVIR
Thursday 7 May, 2026
Introduction: The antiretroviral drug dolutegravir (DTG) inhibits the renal organic cation transporter 2, the primary elimination pathway for the glucose-lowering…
Read morePopulation Pharmacokinetic Modeling of Vancomycin in Ventricular Assist Device Implanted Patients: Exploration for Role of Hemodynamic Parameters
Thursday 7 May, 2026
Introduction/Objectives: Ventricular assist devices (VADs) are implantable mechanical pumps used in advanced heart failure as bridge-to-transplantation or destination therapy. Despite…
Read moreAn individual patient data meta-analysis of miltefosine pharmacokinetics across clinical forms of leishmaniasis
Thursday 7 May, 2026
Objectives: Miltefosine is the only oral treatment for all clinical forms of leishmaniasis, ranging from self-healing cutaneous leishmaniasis (CL) to…
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