Thursday 16 October, 2025
Introduction: Rifampicin remains one of the most critical drugs in the treatment of tuberculosis (TB) (1). Yet its clinical efficacy,…
Read morePoster: Drug/Disease Modelling - Infection
Mechanism-based model of the innate immune response in bacteraemia to assess antibiotic PK/PD targets in immune competent and immune compromised hosts
Thursday 16 October, 2025
Introduction The role of immune status is currently scarcely considered in antibiotic dose selection and treatment [1–3]. It has been…
Read morePopulation pharmacokinetics of colistimethate sodium following intravenous administration in critically ill South African adults
Thursday 16 October, 2025
Introduction/Objectives: The growing global burden of infections caused by multidrug resistant gram-negative bacteria (MDR-GNB) necessitates appropriate choice and dosing of…
Read morePopulation Pharmacokinetics of Dolutegravir: A Narrative Review
Thursday 16 October, 2025
Introduction: Dolutegravir (DTG) is a widely used integrase inhibitor for HIV treatment due to its efficacy and safety. It is…
Read morePopulation pharmacokinetics of amikacin in Indian patients with multi-drug-resistant tuberculosis
Thursday 16 October, 2025
Objectives: In 2023, India accounted for 27% of global multi-drug-resistant tuberculosis (MDR-TB) cases and ranked in the top-decile of countries…
Read morePharmacokinetics of ethambutol and weight banded dosing in South African adults newly diagnosed with tuberculosis and HIV
Thursday 16 October, 2025
Introduction: Ethambutol is used to treat tuberculosis (TB) in individuals living with human immunodeficiency virus (HIV). Low concentrations of ethambutol…
Read moreInformativeness of different in vitro Mycobacterium tuberculosis culture phases in time-kill assay for pharmacokinetic-pharmacodynamic translation
Thursday 16 October, 2025
Introduction: In preclinical settings, the response of Mycobacterium tuberculosis to drug exposure can be observed through in vitro experiments such…
Read moreRepeated-time-to-event modelling predicting respiratory tract infections during the COVID-19 pandemic
Thursday 16 October, 2025
Introduction/Objectives: Respiratory tract infections (RTIs) cover a broad family of diseases, which also includes the coronavirus disease (COVID-19). COVID-19, declared…
Read moreMechanistic viral dynamic modeling of in vitro cytomegalovirus infection based on the amount of viral DNA and viral titer
Thursday 16 October, 2025
Introduction Cytomegalovirus (CMV) is a herpesvirus which is one of the major complications in solid organ and stem cell transplant…
Read moreAn interactive pharmacokinetic, pharmacodynamic, and long-term outcome model framework to evaluate bedaquiline dose modifications in adults with tuberculosis
Thursday 16 October, 2025
Objectives: Bedaquiline (BDQ) has been shown to improve treatment outcomes in multidrug-resistant tuberculosis (TB) and is a key component in…
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