Thursday 16 October, 2025
Objectives: M5717 is a novel antimalarial under development for single-dose treatment, transmission blocking and chemoprotection (1). It has a long…
Read morePoster: Drug/Disease Modelling - Infection
Antimicrobial Drug Development Common Practices in PK-PD Model Selection and Common Misconceptions
Thursday 16 October, 2025
Introduction: For antimicrobial drug development, relationship between efficacy and indices of exposure (e.g. AUC, Cmax ,%Time above MIC) are often…
Read moreModelling the dynamics of bacterial colonisation in a murine model of Urinary Tract Infections
Thursday 16 October, 2025
Objectives: Urinary tract infections (UTIs) are the second most widespread infections globally and present high recurrence rates, with Escherichia coli…
Read moreAn HCV nucleoside inhibitor MK-3682 minimal PBPK-PD model for application in hypothesis generation regarding metabolic pathways and perturbations under various conditions
Thursday 16 October, 2025
Objectives: MK-3682 is a uridine nucleoside monophosphate prodrug inhibitor of HCV NS5B RNA polymerase. To support the understanding of its…
Read morePopulation pharmacokinetics of teicoplanin in preterm and term neonates with late-onset sepsis
Thursday 16 October, 2025
Objectives: Although glycopeptides are among the most commonly used antimicrobials in neonates with suspected late-onset sepsis, little is known about…
Read morePharmacokinetic-pharmacodynamic modelling of MK-2048 in ex vivo cervical tissue
Thursday 16 October, 2025
Objectives: An estimated 1.8 million individuals worldwide acquired new HIV infections in 2016; the equivalent of around 5,000 new infections…
Read moreAn immune quantitative framework for Hepatitis B viral infection
Thursday 16 October, 2025
Objectives: Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver, a known…
Read moreA mechanistic model describing antibody response and SARS-CoV-2 viral loads
Thursday 16 October, 2025
Introduction The COVID-19 pandemic has been marked by the continuous evolution of SARS-CoV-2, with emerging variants exhibiting diverse transmissibility and…
Read morePopulation Pharmacokinetic Modeling of Amoxicillin in Penguins
Thursday 16 October, 2025
Introduction/Objective: Antibiotic administration in penguins is often performed empirically due to this species’ lack of pharmacokinetic (PK) data on drug…
Read moreMathematical modeling of immune response following mRNA- or protein-based vaccine for SARS-CoV-2
Thursday 16 October, 2025
Introduction: Vaccination is the most effective and economical intervention for controlling the spread of epidemics, and various techniques have been…
Read more