Thursday 16 October, 2025
Objectives: The aim of this study is to investigate the population pharmacokinetic (PK) profiles of meropenem in Korean patients with acute…
Read morePoster: Drug/Disease Modelling - Infection
Effect of Pharmacokinetic Model Misspecification on Antibiotic Probability of Target Attainment Predicted by Monte Carlo Simulation
Thursday 16 October, 2025
Objectives: Many population pharmacokinetic (PK) models have been developed for an antibiotic, and the structures of such models are very diverse….
Read moreBeyond One-Size-Fits-All: Tailoring Teicoplanin Regimens for Normal Renal Function Patients with Population Pharmacoki-netics and Monte-Carlo Simulation
Thursday 16 October, 2025
Objectives: Teicoplanin, along with vancomycin, a glycopeptide antibiotic, plays a pivotal role in the treatment of gram-positive bacterial infections, including…
Read moreA Novel Mechanism-Based Pharmacokinetic-Pharmacodynamic Model Describing Ceftazidime-Avibactam (CAZ-AVI) Efficacy Against β-lactamase-Producing Klebsiella pneumoniae and Pseudomonas aeruginosa Isolates
Thursday 16 October, 2025
Objectives: To develop a mechanism based PKPD model describing the interaction between the diazabicyclootance (DBO) β-lactamase inhibitor Avibactam (AVI) and…
Read morePopulation Pharmacokinetics of Belimumab Administered Intravenously in Children with Systemic Lupus Erythematosus
Thursday 16 October, 2025
Introduction Belimumab (BENLYSTA) is a human IgG1λ monoclonal antibody that neutralizes B-lymphocyte stimulator protein (BLyS; also known as B-cell activating…
Read moreMultidrug-resistant genotypes are associated with therapeutic failure of antimalarial therapy in Cambodia; a pharmacometric approach
Thursday 16 October, 2025
Objectives: Artemisinin-based combination therapy is the recommended first-line treatment for malaria. However, recent data report emerging multi-drug resistant falciparum malaria…
Read morePharmacokinetics and pharmacodynamics of ivermectin and its metabolites
Thursday 16 October, 2025
Objectives: Ivermectin is a drug which has been used in the treatment of several different diseases. It has also been shown…
Read morePharmacokinetics/pharmacodynamics and exposure-response modelling of VH3810109 (N6LS) in antiretroviral therapy-naïve adults with HIV-1 from the Phase IIa BANNER Study
Thursday 16 October, 2025
Objectives: Broadly neutralizing antibodies (bnAbs) are under development for both the treatment and prevention of HIV-1. VH3810109 (N6LS) is a…
Read moreClinical Model-Based Meta-Analysis applied to Vaccine Development for SARS-CoV-2 Variants
Thursday 16 October, 2025
Objectives: Kandala et al [1] showed how the model based meta-analysis (MBMA) approach can be successfully applied to enable decision making…
Read morePharmacokinetic-Pharmacodynamic (PKPD) model of Rilpivirine in HIV-1-infected patients treated with the single-tablet regimen rilpivirine/tenofovir/emtricitabine
Thursday 16 October, 2025
Objectives: Rilpivirine (RPV) is a non-nucleoside reverse transcriptase inhibitor widely prescribed for the treatment of HIV-1 infection both in naïve…
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