Thursday 16 October, 2025
Introduction: Pseudomonas aeruginosa is the most common microorganism involved in many ICU-acquired infections. This bacterium presents a remarkable capacity to…
Read morePoster: Drug/Disease Modelling - Infection
In vitro pharmacodynamic drug-drug interaction and translational evaluation of cabamiquine and pyronaridine as new antimalarial combination using P.falciparum field isolates
Thursday 16 October, 2025
Objectives Every year, malaria continues to inflict extensive morbidity and mortality in resource-poor countries. In recent decades, new interventions, such…
Read moreNanoscale pharmacokinetics and pharmacodynamics of isoniazid treatment of tuberculosis in zebrafish larvae
Thursday 16 October, 2025
Objectives: In tuberculosis (TB) research, the zebrafish (1) proves a promising model organism, because the aquatic pathogen Mycobacterium marinum, shows…
Read morePKPD modelling of EYP001a (a novel FXR agonist) in healthy volunteers and Hepatitis B patients
Thursday 16 October, 2025
Objectives: EYP001a is an agonist of the nuclear farnesoid X receptor (FXR) which binds bile acids. FXR agonists, originally discovered…
Read morePopulation pharmacokinetics and cardiovascular safety of piperaquine in African patients with uncomplicated malaria
Thursday 16 October, 2025
Objectives: Develop a PK/PD model to describe the relationship between piperaquine exposure and QT-prolongation in order to evaluate the cardiovascular safety…
Read moreSemi-mechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria
Thursday 16 October, 2025
Objectives: Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for Plasmodium falciparum malaria. Piperaquine is also under consideration for other…
Read moreA pediatric population pharmacokinetic model for ethionamide in South African children treated for drug-susceptible or drug-resistant tuberculosis.
Thursday 16 October, 2025
Objectives: As drug resistant tuberculosis becomes more prevalent, improved knowledge of drugs also beyond first-line treatment becomes increasingly important. Ethionamide…
Read moreModel-based translation from piglets to healthy volunteers: Prediction of TNF-α and IL-6 time-courses in human endotoxin challenge studies
Thursday 16 October, 2025
Objectives: Endotoxins (ETX), also known as lipopolysaccharides (LPS), are components in the plasma membrane of Gram-negative bacteria that lead to…
Read morePredictors of treatment outcomes in children with rifampicin-resistant tuberculosis: a global individual patient data meta-analysis
Thursday 16 October, 2025
Introduction: Out of the approximately 1.1 million children worldwide who were diagnosed with tuberculosis in 2020, it is estimated that…
Read morePopulation Pharmacokinetic Modeling of Simeprevir – Odalasvir Interaction in Healthy Volunteers
Thursday 16 October, 2025
Objectives: To develop a joint population (pop) pharmacokinetic (PK) model describing the PK interaction between simeprevir (SMV) and odalasvir (ODV), two…
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