Thursday 16 October, 2025
Introduction: Para-aminosalicylic acid (PAS) is one of the essential add-on Group C medicines recommended by the World Health Organisation for the…
Read morePoster: Drug/Disease Modelling - Infection
Optimization of dosing strategy for Colistin using population pharmacokinetic model based on the Bayesian inference
Thursday 16 October, 2025
Objectives : With increasing incidence of infections caused by multi drug resistance (MDR) Gram negative pathogen and paucity of new…
Read morePopulation Pharmacokinetics and Model-Informed Precision Dosing of Isoniazid in Tuberculosis Patients
Thursday 16 October, 2025
Objectives: Isoniazid (INH) is a drug used in the first-line treatment of tuberculosis (TB). Interindividual variability (IIV) of INH pharmacokinetics…
Read moreModeling the relationship between plasma and intracellular pharmacokinetics of bedaquiline and its metabolite M2 in South African patients with rifampicin-resistant tuberculosis
Thursday 16 October, 2025
Objectives: Tuberculosis is one of the leading causes of mortality from a single pathogen worldwide [1]. Meanwhile, drug-resistant tuberculosis is…
Read morePhysiological Response to Endotoxin Infusion in the Piglet: Modelling of changes in hemodynamic outcomes
Thursday 16 October, 2025
Introduction: Sepsis is a life-threatening clinical condition resulting from exaggerated immune activation, often in response to bacterial infection, and it…
Read morePharmacokinetics of vancomycin in the cerebrospinal fluid in critically ill patients
Thursday 16 October, 2025
Introduction: Although the penetration into the central nervous system is believed to be poor, vancomycin is the recommended therapy in…
Read moreA Pharmacokinetic-Pharmacodynamic model built on in vitro data predict the antibacterial effect of polymyxin B against Klebsiella pneumoniae in vivo
Thursday 16 October, 2025
Introduction: Pharmacokinetic-Pharmacodynamic (PKPD) models built on preclinical data can be a useful tool for efficient exploration of antibiotic effects. Polymyxin B…
Read moreQuantitative comparison of in vitro and in vivo variability of microdialysis experiments using nonlinear mixed-effects modelling on the example of linezolid
Thursday 16 October, 2025
Objectives: Developing and finding the optimal dosing regimen of antiinfectives with the goal of optimising therapeutic outcome and preventing the…
Read morePopulation pharmacokinetics of benznidazole as monotherapy and in combination with fosravuconazole in adult patients with chronic Chagas disease (BENDITA study)
Thursday 16 October, 2025
Introduction: Chagas disease (American trypanosomiasis) is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi and can lead…
Read morePharmacokinetic-pharmacodynamic analysis of DNDi-6148 in pre-clinical models of visceral leishmaniasis
Thursday 16 October, 2025
Introduction: Visceral leishmaniasis (kala-azar) is a neglected tropical disease caused by Leishmania parasites (L. donovani and L. infantum) and can be…
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