Thursday 16 October, 2025
Introduction: Vancomycin is a widely-used antibiotic with a narrow therapeutic range. Elevated levels may lead to nephrotoxicity, while insufficient levels…
Read morePoster: Drug/Disease Modelling - Infection
Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) combinations: should we monitor the BLI concentration?
Thursday 16 October, 2025
Introduction: In order to restore the activity of β-lactam (BL) drugs against β-lactamase-producing bacteria, several combinations of a BL and…
Read moreA simulation-based evaluation of the pharmacokinetic-pharmacodynamic (PK/PD) index approach for avibactam
Thursday 16 October, 2025
Introduction: β-lactamase inhibitors (BLI) are an increasingly important group of drugs, used to restore the activity of β-lactam (BL) antibiotics…
Read moreSemi-mechanistic PK modelling of drug-macrophage interactions affecting the disposition of liposomal amphotericin B in plasma and skin tissue of post kala-azar dermal leishmaniasis patients
Thursday 16 October, 2025
Objectives: Leishmaniasis is a neglected parasitic tropical disease, clinically characterized by a large production of macrophages in which Leishmania parasites…
Read moreApplying PKPD modelling to evaluate the impact of plasma proteins in time-kill experiments; does the protein binding matter?
Thursday 16 October, 2025
Background: In vitro time-kill models offer a platform for studying antibiotic PKPD, potentially translatable to in vivo effects via PKPD…
Read moreA pharmacometric model on cytokine changes upon live Escherichia coli exposure in a porcine sepsis model
Thursday 16 October, 2025
Objectives: Effective sepsis management is challenged by sepsis heterogeneity and the lack of clear understanding of the time course of…
Read morePharmacometric analysis to explore moxidectin treatment with and without albendazole in Trichuris trichiura-infected adolescents
Thursday 16 October, 2025
Introduction: Moxidectin is a promising drug candidate that has the potential to complement the depleted drug arsenal against infections with…
Read moreCharacterization of SARS-CoV-2 variants of concern viral dynamics in non-human primates
Thursday 16 October, 2025
Introduction Since the beginning of the pandemic several SARS-CoV-2 variants have emerged and although most of them vanished quickly, some…
Read moreRelative bioavailability of delamanid dispersed in water in healthy volunteers
Thursday 16 October, 2025
Objectives: Delamanid is a nitro-dihydro-imidazooxazole antibiotic which derives its antimycobacterial activity from inhibiting mycolic acid synthesis. A delamanid tablet of…
Read morePopulation pharmacokinetics of moxifloxacin in Indian patients with multi-drug resistance tuberculosis
Thursday 16 October, 2025
Introduction: Moxifloxacin (MFX) is an 8-methoxy quinolone metabolized in the liver through sulfate and glucuronide conjugation by uridine diphosphate- glucuronosyltransferases…
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