Thursday 16 October, 2025
Objectives: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder and has serious impacts on our lives. Most existing…
Read morePoster: Drug/Disease Modelling - Endocrine
Amisulpride: Real-World Evidence of Dose Adaptation and Effect on Prolactin levels using PK/PD modeling
Thursday 16 October, 2025
Objectives: Amisulpride is administered orally at a wide range of doses (100-800 mg daily) for treating schizophrenia. Therapeutic drug monitoring of…
Read moreA Semi-Physiologic Model of Postprandial Triglyceride Response following Anti-Obesity Therapy
Thursday 16 October, 2025
Objectives: Obesity is a disorder of chronic positive energy balance, whereby excess of energy intake beyond energy utilization leads to…
Read moreA Categorical Model of Sweet/Fat Preference Taste in Lean, Obese and Very Obese Subjects
Thursday 16 October, 2025
Introduction/Objectives: Obesity is a disorder of chronic positive energy balance, whereby excess of energy intake beyond energy utilization leads to…
Read moreDapagliflozin pharmacokinetics is similar in adults with type 1 and type 2 diabetes mellitus
Thursday 16 October, 2025
Objectives: Dapagliflozin is a highly potent, selective, and reversible inhibitor of sodium-glucose cotransporter 2 (SGLT2) that improves glycaemic control in…
Read morePopulation concentration-QTc modeling of anti-PCSK9 antisense oligonucleotide
Thursday 16 October, 2025
Objectives: AZD8233 is a proprotein convertase subtilisin/kexin type 9 (PCSK9)-targeted, N-acetylgalactosamine (GalNAc)-conjugated anti-sense oligonucleotide specifically inhibiting PCSK9 expression in the…
Read morePopulation Pharmacokinetic and exposure-efficacy Markov modelling of enzymatic activity in Gaucher disease patients treated with enzyme replacement therapy
Thursday 16 October, 2025
Objectives: The aim of this study is (i) to develop a population pharmacokinetic model of enzyme activity in Gaucher disease…
Read moreLongitudinal Model-Based Meta-Analysis for Liver Biomarkers and Biopsy Endpoints in Patients with Non-Alcoholic Fatty Liver Disease
Thursday 16 October, 2025
Objectives: Non-Alcoholic Fatty Liver Disease (NAFLD) is defined by excessive hepatic fat accumulation (steatosis, defined as a liver fat content…
Read moreModel-Based Meta-Analysis of Triglyceride Reduction in Patients with Hypertriglyceridemia
Thursday 16 October, 2025
Objectives: Model-based meta-analysis (MBMA) was conducted to quantify the changes in lipid endpoints including triglycerides (TG) achieved by interventions in…
Read moreConditional linear mixed-effect modelling of HbA1c and fasting glucose in diabetic patients shows that progression rates for the two variables are different: an IMI DIRECT study
Thursday 16 October, 2025
Objectives: Research on personalization of treatment for type 2 diabetes (T2D) requires the study of the individual rate of disease…
Read more