Thursday 16 October, 2025
Objectives: Tacrolimus is an immunosuppressive agent, largely used in kidney transplantation. The objectives of this study were to develop the…
Read morePoster: Covariate/Variability Model Building
High-throughput genetic screening and pharmacokinetic population modeling in drug development
Thursday 16 October, 2025
Objectives: To develop a population PK model and integrate a large number of SNPs, genotyped in clinical studies, as covariates…
Read moreEvaluation of FREM and FFEM including use of model linearization
Thursday 16 October, 2025
Objectives: In full model approaches, covariate relations are predefined [1]. Attaching covariate relations selectively to only some of the model…
Read moreUsing Population PBPK Modelling to interpret Population PK results exemplified for Levofloxacin in Plasma and Interstitial Fluid
Thursday 16 October, 2025
Objectives: A key aim of covariate modelling is to represent the influence of covariates on PK parameters. Structural parameters, e.g….
Read morePopulation pharmacokinetics of belimumab in systemic lupus erythematosus: insights for monoclonal antibody covariate modeling from a large data set
Thursday 16 October, 2025
Objectives: Belimumab is a recombinant, human immunoglobulin (Ig)-G1λ monoclonal antibody (mAb) that targets B-lymphocyte stimulator (BLyS), a cytokine that promotes…
Read morePharmacokinetic/pharmacodynamic (PK/PD) Analysis of Teriflunomide in Patients with Relapsing Forms of Multiple Sclerosis (RMS)
Thursday 16 October, 2025
Objectives: To explore the relationship between 12 safety and 6 efficacy variables and steady-state mean Teriflunomide trough concentrations (MCONC) in…
Read moreCharacterization of Stepwise Covariate Model Building Combined with Cross-Validation
Thursday 16 October, 2025
Objectives: We reported on a stepwise covariate model building combined with cross-validation (XV SCM) [1]. This method is useful to…
Read moreEvaluating the effect of CYP3A4 and CYP3A5 polymorphisms on cyclosporine, everolimus and tacrolimus pharmacokinetics in renal transplantation patients.
Thursday 16 October, 2025
Objectives: Cyclosporine, everolimus and tacrolimus form the cornerstone of maintenance immunosuppressive therapy in renal transplantation. These drugs have a small…
Read moreIndividual Observation-Shrinkage Scaling of Residuals in a Generalized Least Square Type of Estimation in NONMEM
Thursday 16 October, 2025
Objectives: A generalized least square (GLS) type of approach is often used in regression analysis where the predictions from a…
Read moreTotal plasma protein and haematocrit influence on tacrolimus clearance in kidney transplant patients – population pharmacokinetic approach
Thursday 16 October, 2025
Objectives: Tacrolimus is a low-clearance drug extensively bound to erythrocytes and highly protein bound. The aim of the study was…
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