Thursday 16 October, 2025
Introduction/Objectives: For patients with severe respiratory or heart failure, extracorporeal membrane oxygenation (ECMO) is a life-saving treatment [1]. However, ECMO…
Read morePoster: Clinical Applications
A precision dosing application for docetaxel in metastatic prostate cancer
Thursday 16 October, 2025
Introduction: The therapeutic window of chemotherapy drugs is commonly established at a population level and patient dose selection is often…
Read moreThe use of a Bayesian dosing tool to optimise enoxaparin treatment: a pilot clinical study
Thursday 16 October, 2025
Objectives: Enoxaparin is a widely used anticoagulant in the treatment of thrombosis. Due to its narrow therapeutic window, monitoring of…
Read morePopulation pharmacokinetics of Jesduvroq (daprodustat) in chronic kidney disease patients with anemia
Thursday 16 October, 2025
Objectives: Jesduvroq (daprodustat) is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI). It is approved for the treatment of anemia in…
Read moreContinuous learning in model-informed precision dosing: a case study
Thursday 16 October, 2025
Background: Model-informed precision dosing (MIPD) has the potential to optimize drug dosing for many narrow-therapeutic window and biomarker-guided drugs.[1-3] However,…
Read moreTherapeutic drug monitoring strategies for Envarsus in de novo renal transplant patients using population modelling and simulations
Thursday 16 October, 2025
Objectives: Tacrolimus is a pivotal immunosuppressant agent used in solid-organ transplantation necessitating therapeutic drug monitoring (TDM), due to its narrow…
Read morePopulation Pharmacokinetic Modeling of Leriglitazone in Healthy Volunteers and Patients with Neuro-degenerative Disorders – Exploring dosing schedules in children with adrenoleukodystrophy via simulations
Thursday 16 October, 2025
Introduction: Leriglitazone is a full, selective and brain penetrant peroxisome proliferator-activated receptor gamma (PPARγ) agonist. The compound is a promising…
Read morePopulation modelling and simulations of binimetinib pharmacokinetics in subjects with hepatic impairment to explore optimal dosing regimen using total and unbound binimetinib exposures
Thursday 16 October, 2025
Objectives: Binimetinib is a potent and selective inhibitor of MEK 1 and MEK 2. Binimetinib is indicated for use in…
Read moreRational dosing of caffeine using target concentration intervention to improve treatment of apnea of prematurity
Thursday 16 October, 2025
Objective: Apnea of prematurity (AOP) is defined as an attack of apnea for at least 20 seconds, with bradycardia and…
Read moreA Physiological Approach to Renal Clearance – from Premature Neonates to Adults
Thursday 16 October, 2025
Objectives: A physiological basis to hepatic drug clearance has been widely applied based on the identification of hepatic blood flow…
Read more