Thursday 16 October, 2025
Objectives: As part of a post-marketing study performed to clarify the potential activity of dolasetron on ventricular repolorization, a secondary…
Read morePoster: Cardiovascular, QT-prolongation
Relevance of QT-RR correlations in the assessment of QTc-interval prolongation in clinical trial simulations
Thursday 16 October, 2025
Objectives: Correction for changes in heart rate is a fundamental step to the evaluation of QTc-interval prolongation. Yet, clinical trial…
Read morePopulation modelling of blood pressure: assessing clinically important factors for cardiovascular diseases
Thursday 16 October, 2025
Objectives: Blood pressure exhibits diurnal variation with a chronobiological (circadian) rhythm with an increase in the morning and a decrease…
Read morePKPD Modelling Of Cardiovascular Safety Pharmacology Data
Thursday 16 October, 2025
Objectives: Modelling and simulation (M&S) techniques are now commonly used to analyse clinical pharmacokinetic (PK) and pharmacodynamic (PD) data as…
Read moreProbabilistic risk assessment for QT prolongation and heart rate increase
Thursday 16 October, 2025
Objectives: Oral drug A is in clinical development for several indications between Proof-of-Concept and Phase II. The objective of the…
Read moreInterspecies differences in moxifloxacin-induced QTc-interval prolongation
Thursday 16 October, 2025
Objectives: Assessment of the propensity of non-antiarrhythmic drugs in prolonging QT/QTc-interval is critical for the progression of compounds into clinical…
Read morePharmacodynamics of nadroparin using anti-Xa levels in morbidly obese patients upon subcutaneous administration of 5700 IU
Thursday 16 October, 2025
Objectives: Morbidly obese patients (body mass index (BMI) > 40 kg/m2) are at increased risk for thromboembolism, especially after surgery….
Read moreCan First-Time-In-Human Trials Replace Thorough QT Studies?
Thursday 16 October, 2025
Objectives: The aim of the present study was to investigate if the first-time-in-human (FTIH) trials can be modified and optimised…
Read moreMeta-Analysis of Antiplatelets in Patients with Atrial Fibrillation: A survival Model
Thursday 16 October, 2025
Objectives: Warfarin reduces the risk of stroke in patients with atrial fibrillation; however, due to multiple interactions, coagulation monitoring and dose…
Read moreQuantitative understanding of drug effects on the interrelationship between mean arterial blood pressure, cardiac output and total peripheral resistance
Thursday 16 October, 2025
Objectives: Since persistent hypertension is a risk factor for heart failure and is a leading cause of cardiovascular disease, evaluating…
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