Thursday 16 October, 2025
Motivation: Systems modeling approaches are seen as the next step in the evolution of mechanism-based pharmacokinetic-pharmacodynamic (PKPD) modeling. However, while…
Read morePoster: Applications- Other topics
Effect Of Clonidine On Bupivacaine Clearance In Tunisian Patients: Population Pharmacokinetic Investigation.
Thursday 16 October, 2025
Objectives: Combined lumbar and sciatic nerve blocks is associated with an increased plasmatic concentrations of bupivacaine, reaching sometimes toxic concentrations,…
Read morePhase I trials: Model-based assessment to identify a clinical relevant change in heart rate
Thursday 16 October, 2025
Objectives: The primary objective of this work was to ascertain, through an integrated PK/PD model-based approach, what measure of change…
Read moreOnce Daily Pharmacokinetics Of Lamivudine In HIV-Infected Children
Thursday 16 October, 2025
Objectives: The use of antiretroviral (ARV) drugs in children imposes careful considerations regarding dosing frequency and patient compliance. There may…
Read moreModel-based evaluation of DAS28 as a potential surrogate for ACR20 to establish the dose-response relationship for disease modifying anti-rheumatic drugs. A case study using tasocitinib (CP-690,550), an oral JAK inhibitor.
Thursday 16 October, 2025
Background: Tasocitinib (CP-690,550), a selective inhibitor of the Janus kinase (JAK) family, is being developed for the treatment of several…
Read morePredicting glomerular filtration rate using clearance of amikacin
Thursday 16 October, 2025
Objectives: Throughout childhood many physiological changes occur. In addition, renal function is influenced by physiological changes resulting in differences in…
Read morePK modelling of organophosphorus poisoning in humans
Thursday 16 October, 2025
Objectives: Organophosphorus (OP) pesticide poisoning is an important problem in South Asia, acute poisoning from OP’s in Sri Lanka resulted…
Read moreBayesian Network Approach to Modeling Spinal Muscular Atrophy Populations
Thursday 16 October, 2025
Background & Objectives: Proximal recessive Spinal Muscular Atrophy (SMA) is the most frequent heritable lethal disease in infants and a…
Read moreJoint model for dropout in longitudinal trials in COPD patients
Thursday 16 October, 2025
Objectives: Long term longitudinal studies often have large dropout rates. The dropout is termed informative if it is related to…
Read moreScaling clearance of propofol from preterm neonates to adults using an allometric model with a bodyweight-dependent maturational exponent
Thursday 16 October, 2025
Objectives: For propofol clearance, allometric scaling has been applied successfully for between species scaling and for scaling within a certain…
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