Thursday 16 October, 2025
High dose chemotherapy (HDC) and peripheral blood stem-cells transplantation (PBSCT) is a therapeutic strategy, which seems to improve disease free…
Read morePoster: Applications- Oncology
Pharmacodynamic (PD) Modelling of Anti-Proliferative Effects of Tetraiodothyroacetic Acid (Tetrac) on Human Cancer Cells
Thursday 16 October, 2025
Objectives: Tetraiodothyroacetic acid (tetrac), a deaminated analogue of L-thyroxine (T4), competes with T4 to bind to the integrin αvβ3 receptor…
Read moreNew model for gemcitabine and its metabolites
Thursday 16 October, 2025
Objectives: Gemcitabine is a prodrug with proved efficacy in different tumors as lung or pancreas cancer. It is intracellulary actived…
Read moreComparison between NONMEM and NPAG for gemcitabine modelling
Thursday 16 October, 2025
Objectives: Gemcitabine is a prodrug with proved efficacy in diferents tumors as lung or pancreas cancer. There is a good…
Read moreAllometric scaling in oncology disease progression from xenograft tumor growth to human non-small-cell lung cancer
Thursday 16 October, 2025
Objectives: Derive an allometric conversion between published models on tumor volume of human cell lines in xenografts and on clinically…
Read moreModelling of PK/Efficacy/Toxicity in rats to help design a First Human Dose for a cell cycle inhibitor X
Thursday 16 October, 2025
Objective: The primary objective of PK/PD modelling in preparation of the FHD study was to estimate a pharmacologically effective and…
Read moreMatuzumab – A Population Pharmacokinetic Model and its Evaluation
Thursday 16 October, 2025
Objectives: Matuzumab is a humanised monoclonal antibody (mAb) of the immunoglobulin subclass IgG1 which targets the epidermal growth factor receptor…
Read moreMatuzumab – Evaluation of the Population Pharmacokinetic Model and Analyses of the Covariate Impact on the Pharmacokinetic Profile
Thursday 16 October, 2025
Objectives: Matuzumab is a humanised monoclonal antibody of the immunoglobulin subclass IgG1 which targets the epidermal growth factor receptor (EGFR)….
Read morePopulation Pharmacokinetic Analysis for Matuzumab (EMD 72000) – A Humanised EGFR-Targeted Monoclonal Antibody
Thursday 16 October, 2025
PDF of poster Objectives: Matuzumab, a humanised monoclonal antibody (mAb), targets the epidermal growth factor receptor (EGFR) and has shown…
Read morePopulation pharmacodynamic model of the effects of recombinant human interleukin 21 on platelets in humans
Thursday 16 October, 2025
PDF of poster Objectives: Interleukin-21 is a cytokine that is produced by activated CD4+ T cells and increases proliferation, activity…
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