Thursday 16 October, 2025
Objectives: Although beta-adrenoceptor-blockers have been proven to reduce morbidity and mortality in adult congestive heart failure, there is not enough…
Read morePoster: Applications- CVS
Translation of drug-induced QTc prolongation in early drug development.
Thursday 16 October, 2025
Objectives: Assessment of the propensity of non-antiarrhythmic drugs in prolonging QT/QTc interval is critical for the progression of compounds into…
Read morePrediction of Torsades de Pointes from QT interval: analysis of a case series with amisulpride
Thursday 16 October, 2025
Background and objectives: Torsades de Pointes (TdP) is a potentially fatal ventricular arrhythmia that is associated with a drug-induced QT…
Read moreNot-In-Trial Simulation: Predicting cardiovascular risk from clinical trial data
Thursday 16 October, 2025
Objectives: The objective of this study is to better translate clinical findings to real life situations and resolve the discrepancies…
Read moreNot-in trial simulation : Prospective use of Not-In-Trial Simulation
Thursday 16 October, 2025
Objectives: Previously, the concept of Not-In-Trial Simulation model was introduced to describe QTc in a real life cohort using a…
Read moreAn integrated whole-body physiology based pharmacokinetic/pharmacodynamic model of enalapril and the RAA-system
Thursday 16 October, 2025
Objectives: Integrated physiology based (PB) modelling could provide comprehensive platforms to simulate the mechanistic interactions between the pharmakokinetic and pharmacodynamic…
Read morePharmacokinetic Model for Losartan Administered to Young Mexican Healthy Volunteers.
Thursday 16 October, 2025
Objectives: To evaluate the pharmacokinetics of Losartan (100 mg) in a Young Healthy Volunteers Mexican Population. Methods: Eighty two healthy volunteers of both…
Read morePharmacokinetics model for Nifedipine administered to Healthy Volunteers.
Thursday 16 October, 2025
Objectives: Nifedipine pharmacokinetics a great variability on clearance due to genetic polymorphisms and food-drug interaction. In Mexicans [1] the clearance…
Read moreBayesian Modeling of QT Interval: Focus on Baseline Measurements
Thursday 16 October, 2025
Detecting drug-induced effects on cardiac repolarization, measured by the length of the QT interval on an ECG, is a closely…
Read morePopulation Pharmacokinetic-Pharmacodynamic Analysis of Weight Loss Efficacy of CP-945,598 in Adult Obese Subjects
Thursday 16 October, 2025
Objectives: To characterize the time course of weight loss efficacy of CP-945,598 (CP) in obese subjects following multiple oral doses…
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