Thursday 16 October, 2025
Objectives: Vigabatrin is an anti-epileptic drug used for the treatment of infantile spams. Vigabatrin has been identified as a substrate…
Read morePoster: Absorption and Physiology-Based PK
Usefulness of Weibull-Type Absorption Model for the Population Pharmacokinetic Analysis of Pregabalin
Thursday 16 October, 2025
Objectives: Pregabalin is an anticonvulsant used for the treatment of neuropathic pain and partial seizure in adults. The aim of…
Read moreCharacterisation of different absorption rate constants after inhalation of olodaterol
Thursday 16 October, 2025
Objectives: As there is a lack of quantitative mechanistic understanding about plasma concentration-time profiles after inhalation of drug formulations, the…
Read moreQualitative prediction of human oral bioavailability from animal oral bioavailability data employing ROC analysis
Thursday 16 October, 2025
Objectives: The aim of this study was to develop a Receiver Operating Characteristic (ROC) analysis to evaluate the performance of…
Read moreA mechanistic population pharmacokinetic model for simvastatin and its active metabolite simvastatin acid
Thursday 16 October, 2025
Objectives: Simvastatin (SV), a commonly used HMG-CoA reductase inhibitor, is a prodrug with complex pharmacokinetics due to the interconversion between the…
Read moreA Physiologically-Based Pharmacokinetic Model for Busulfan
Thursday 16 October, 2025
Objectives: Busulfan (Bu), a DNA-alkylating agent, is used widely for conditioning prior to bone marrow transplantation in both children and…
Read moreDevelopment and application of a mechanistic physiologically based pharmacokinetic model to assess oral drug bioavailability post bariatric surgery in morbidly obese patients
Thursday 16 October, 2025
Objectives: The invasive nature of bariatric surgery, partially restricting the gastrointestinal (GI) tract, has led to observed changes in oral…
Read moreA physiologically based pharmacokinetic model of oral drug bioavailability immediately post bariatric surgery
Thursday 16 October, 2025
Objectives: The prevalence of bariatric surgery has increased dramatically over the last decade. Bariatric surgery leads to changes in the…
Read morePrediction of serum and cerebrospinal fluid concentrations of carbamazepine: An application of parameter estimation and the permeability limited 4-compartment brain model in Simcyp®
Thursday 16 October, 2025
Objective: The objective of the work was to predict the cerebrospinal fluid (CSF) concentration of carbamazepine (CBZ) in humans using…
Read moreThe Pharmacokinetic Profile of Intravenous Paracetamol in Adult Patients Undergoing Major Surgery: A Population Analysis
Thursday 16 October, 2025
Objectives: Intravenous paracetamol is commonly used in the post operative period as part of multimodal analgesia following surgery. [1] Paracetamol…
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