Thursday 16 October, 2025
The ICH E9 guidance requires pre-specification of the data analysis technique for the analysis of the primary variable(s) in the…
Read moreOral: Tutorial
The neurobiology of placebos
Thursday 16 October, 2025
Objectives: The placebo effect has evolved from being thought of as a nuisance in clinical and pharmacological research to a…
Read moreAn overview of Estimation-Maximization Algorithms Used in Population Analysis Methods
Thursday 16 October, 2025
Objectives: To present an overview of expectation-maximization algorithms used to analyse pharmacokinetic/ pharmacodynamics models for population data. Their statistical basis…
Read moreReproducible pharmacometrics
Thursday 16 October, 2025
Reproducibility is the cornerstone of scientific research, but is nonetheless a challenging area in pharmacometric data analysis. The large number…
Read morePhysiologically based pharmacokinetics: Advancing the clinical dimension
Thursday 16 October, 2025
For many years a predominantly academic subject, the application of physiologically-based pharmacokinetic modeling (PBPK) is coming of age in drug…
Read moreLumping of compartments
Thursday 16 October, 2025
Interest in simplification of large mechanistic mathematical models of biological systems which are usually described by differential equations, has increased…
Read moreAn overview of non-parametric estimation methods used in population analysis
Thursday 16 October, 2025
Objectives: To present an overview of non-parametric (NP) estimation methods used to analyze PK/PD population models. Emphasis will be placed…
Read moreIntroduction to Markov modelling
Thursday 16 October, 2025
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A tutorial on time to event analysis for mixed effect modellers
Thursday 16 October, 2025
The connection between PKPD and clinical outcome events can be made using models for time to event. The time of…
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