Thursday 16 October, 2025
Drug development decision making is greatly facilitated by having a model of the likely clinical profile of the new investigational…
Read moreoral presentation
Modelling and simulation of the incidence of adverse events in clinical trials.
Thursday 16 October, 2025
PDF of presentation Objectives: Predict the incidence of a pre-defined adverse event in dose ranging trials of a new compound….
Read moreTransformations and Variance Functions in Nonlinear Mixed-Effects Models
Thursday 16 October, 2025
Population pharmacokinetics (PK) studies consist of longitudinal concentration measurements in a sample of individuals, with the concentration profiles typically being…
Read moreAssessment of the in vivo relative potency of the hydroxylated metabolite of darifenacin for the reduction of salivary flow using a population pharmacokinetic-pharmacodynamic meta-analysis
Thursday 16 October, 2025
Objectives: To estimate the in vivo potency of the hydroxylated metabolite (UK-148,993) to reduce salivary flow (SF) relative to that…
Read moreA Unified Parametric/Nonparametric Approach to PK/PD Population Modeling
Thursday 16 October, 2025
Currently the most popular computational methods for PK/PD population modeling are based on a parametric maximum likelihood (ML) approach that…
Read moreAccurate Maximum Likelihood Estimation for Parametric Population Analysis
Thursday 16 October, 2025
PDF of presentation Objectives: The statistical performance of estimators of fixed and random effects in parametric population PK analyses can…
Read moreExtrapolation of pharmacokinetics and toxicity from pre-clinical data to humans
Thursday 16 October, 2025
Extrapolation of data from animal studies is required to predict pharmacokinetics and/or toxicity in humans during the development of new…
Read moreDevelopment of a PBPK model for drug-drug interaction of orally delivered drugs using in-vitro data
Thursday 16 October, 2025
Early screening systems, like in-vitro preparations of human microsomes can give an indication whether or not a pharmacokinetic interaction between…
Read morePopulation Modelling of the Absolute Bioavailability and Pharmacokinetics of Phenobarbitone in Infants with Seizures
Thursday 16 October, 2025
PDF of presentation Objectives: Seizures occur in 1-2 infants per 1000 term live births and constitute a medical emergency with…
Read moreEstimate the time varying brain receptor occupancy in PET imaging
Thursday 16 October, 2025
Positron-Emission Tomography (PET) is an imaging technology currently used in drug development as a non-invasive measure of drug distribution and…
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