Thursday 16 October, 2025
Population pharmacokinetic is being increasingly applied to individual data collected in different studies without taking into account the random inter-study…
Read moreoral presentation
Clinical Pharmacology = Disease Progress + Drug Action. The role of clinical trial modelling, simulation and analysis using the population PKPD approach.
Thursday 16 October, 2025
The population PKPD approach offers a consistent conceptual framework for understanding the actions of drugs in humans in the context…
Read moreMechanistic and Non-mechanistic Drug Dynamics Modeling
Thursday 16 October, 2025
The mathematical modeling of “drug behavior” has a long tradition. In the modern sense of computer aided mathematical modeling, it…
Read moreMiscellaneous regulatory information
Thursday 16 October, 2025
A presentation/discussion is given on the following topics: 1) What is happening in the European Regulatory enviroment with respect to…
Read moreModeling drug induced changes in biomarkers without using drug concentrations: Introducing the K-PD model
Thursday 16 October, 2025
Biomarkers that trace physiologic or biochemical variations related to drug action are of great interest in early drug development. PK-PD…
Read moreForward selection and other recipes for disaster
Thursday 16 October, 2025
Many population analyses expend a great deal of time and energy on identifying and quantifying covariate effects. Unfortunately, it is…
Read moreModels for sedation scores in acute stroke patients
Thursday 16 October, 2025
Patients often experience sedation following a stroke. The degree and time-course of this sedation will depend of pathophysiological factors, such…
Read moreIron kinetics: when drug loss by sampling is critical in data analysis
Thursday 16 October, 2025
Transferrin bound iron (TBI) is the form in which iron is used by the bone marrow for erythropoiesis. Rapid delivery…
Read moreSensitivity Analysis of PBPK and PK/PD Models
Thursday 16 October, 2025
The undisputed importance of sensitivity analysis (SA) in the modelling practices arises both from the valuable information its results provide…
Read moreMultiple Imputation for Missing-Data Problems
Thursday 16 October, 2025
Multiple imputation (MI) is a general-purpose technique for handling missing data. In MI, each missing value is replaced by M…
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