Thursday 16 October, 2025
PDF of presentation The recent past has seen a considerable increase in the use of flexible and adaptive designs. However…
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Bayesian Population Pharmacokinetic Analysis of Sirolimus
Thursday 16 October, 2025
Objective: It is usual that data collected from routine clinical care is sparse and unable to support the more complex…
Read moreAn adaptive design for dose-response using the Normal Dynamic Linear Model.
Thursday 16 October, 2025
PDF of presentation Objectives: Adaptive designs have an intuitive appeal in the drug development environment where we are trying to…
Read moreA Modeling Approach to Assessing Bioequivalence (BE) with Presence of Sparsely Sampled Subjects
Thursday 16 October, 2025
Objectives: Traditional BE assessment requires the evaluation of a 90% confidence interval (CI) for the ratio of AUC and Cmax…
Read moreDeveloping Integrated Cell Systems
Thursday 16 October, 2025
The strategies and techniques for developing integrated frameworks for systems of molecules, cells, tissues, and organs are complex. The natural…
Read moreDose-Timing Information Improves The Clinical Explanatory Power Of Data On Patient Adherence To Antiretroviral Drug Regimens
Thursday 16 October, 2025
Objectives: Variable adherence to prescribed antiretroviral (ARV) therapy in HIV-infected individuals may result in variable exposure to the ARV drugs…
Read moreUsing Stochastic Differential Equations for PK/PD Model Development
Thursday 16 October, 2025
PDF of presentation Objectives: The objective of this contribution is to demonstrate the benefits of using stochastic differential equations (SDEs)…
Read moreMaximum likelihood estimation in nonlinear mixed effects models
Thursday 16 October, 2025
Objectives : Our aim is to estimate parameters in non linear mixed effects models by maximum likelihood. Some well-knomw used…
Read moreAdaptive dose-finding in two-dimensions: A phase 1 oncology example
Thursday 16 October, 2025
PDF of presentation Cytotoxins are widely used in combination, despite similar toxicities, for example in the bone marrow or gastronintestinal…
Read moreApplications of Distributed computing in Drug development
Thursday 16 October, 2025
Objective: Improve speed and robustness of NONMEM analysis. Methods: Distributed computing is a collection of methods that permit the application…
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