Oral Presentation: Stuart Beal Methodology Session Archives - PAGE Meeting (Population Approach Group Europe)

Advanced Population Analysis Features in the S-ADAPT/MCPEM Program

Thursday 16 October, 2025

Objective: To demonstrate advanced population analysis and simulation abilities of S-ADAPT. Methods: S-ADAPT is a Fortran 95 open-source, free program…

Maximum Likelihood Estimation Methods: Performances in Count Response Models Population Parameters

Thursday 16 October, 2025

Objectives: Count responses represent a full class of common pharmacodynamic outcomes, there is a need for greater knowledge in Non-Linear…

Model Selection Using the Minimum Hellinger Distance Criterion (MHDC) with an Introduction to Minimum Hellinger Distance Estimation (MHDE)

Thursday 16 October, 2025

PDF of presentation Background: Model selection algorithms are prevalent in exploratory exposure-response model development. Of these, likelihood based criteria, such…

Evaluation of the nonparametric estimation method in NONMEM VI beta

Thursday 16 October, 2025

Introduction: In NONMEM VI beta, an option exists for estimation of a nonparametric parameter (eta) distribution. In this, the parameter…

The SAEM algorithm and its implementation in MONOLIX 2.1

Thursday 16 October, 2025

Introduction: The statistical model for most population PK/PD analyses is the nonlinear-mixed effects model (NLMEM). As opposed to linear models,…

What Additional Information Can we Retrieve When Compliance is Accounted For? An explicit Compliance-Pharmacokinetic Formalism

Thursday 16 October, 2025

Objectives: Compliance reflects the patient drug input and has to be considered as a history of drug intake. Quality of…

Conditional weighted residuals, an improved model diagnostic for the FO/FOCE methods.

Thursday 16 October, 2025

PDF of presentation Objectives: Weighted residuals (WRES) are a common diagnostic tool in population model building and evaluation, generally used…

Parameter estimation in non-linear mixed effects models using interval analysis

Thursday 16 October, 2025

Objectives: Parameter estimation for non-linear mixed effects models is an important aspect of model based drug development. Typically, these models…

Evaluation of the PK and PK-PD libraries of MONOLIX: A comparison with NONMEM

Thursday 16 October, 2025

Introduction: The statistical model for most population PK/PD analyses is the nonlinear-mixed effects model (NLMEM). As opposed to linear models,…