Thursday 16 October, 2025
Objectives: During drug discovery, preclinical and clinical drug development, a variety of in vitro and in vivo data are generated…
Read moreOral presentation: Physiology-based modelling
Design of survival studies for red blood cells
Thursday 16 October, 2025
Background: The lifespan of red blood cells (RBCs) is unknown. The primary methods for determining RBC lifespan involve labelling with…
Read moreInvestigation of the Influence of CYP3A4 Inhibition and Renal Impairment on Morphine and M6G Formation after Codeine Administration using Coupled Whole-Body PBPK Modelling
Thursday 16 October, 2025
Objectives: The objective of this study was to systematically investigate the influence of UGT2B7 activity, CYP3A4 inhibition, and renal impairment…
Read moreSemi-mechanistic modeling of absorption from extended release formulations – linking in vitro to in vivo
Thursday 16 October, 2025
Background: The FDA guidance on extended release (ER) formulations (1) states that “Whatever the method used to establish a Level…
Read moreMechanistic Models to Simulate Dose Response of IgE Suppression Following Dosing of Anti-IgE Monoclonal Antibodies
Thursday 16 October, 2025
Objectives: The aim of this study was to use mechanistic models to simulate dose response of IgE suppression for anti-IgE…
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