Thursday 16 October, 2025
Objectives: With approximately 130,000 new cases per year globally, spinal cord injury (SCI) is a global epidemic [1] involving males…
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Mathematical modeling of pulmonary tuberculosis therapy: development of a first prototype model with rifampin
Thursday 16 October, 2025
Objectives: There is a critical need for a shorter tuberculosis (TB) treatment to improve TB control. Current experimental models of TB,…
Read moreConfirmatory Phase III Population Pharmacokinetic Analysis
Thursday 16 October, 2025
Objectives: An important objective in population pharmacokinetics analysis is to assess covariate influence. Results from covariate assessments may be used…
Read moreTime to Event modeling of dropout event in clinical trials
Thursday 16 October, 2025
Background: Dropouts can greatly affect the outcome of clinical trials and a proper understanding of the dropping-out mechanisms is critical…
Read moreEnhancing Methotrexate Pharmacotherapy in Children with Cancer: A Decision Support System Integrating Real-time PK/PD Modeling and Simulation with Patient Medical Records
Thursday 16 October, 2025
Objectives: Methotrexate (MTX) is an anti-folate chemotherapeutic agent used in the therapy of several childhood cancers, including acute lymphoblastic leukemia,…
Read morePopulation TK/TD for chemical risk assessment and drug safety: the cadmium example
Thursday 16 October, 2025
Background: Population pharmacokinetic/pharmacodynamic (PK/PD) models have been largely developed and used in the context of drug development for a number…
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