Thursday 16 October, 2025
PDF of presentation Objectives: Positron emission tomography (PET) is a well-established imaging technique to measure metabolic processes in living subjects….
Read moreOral Presentation: Model Building Session
Model building and model parameter identification for transfer of dioxin TEQs from feed to eggs.
Thursday 16 October, 2025
PDF of presentation Objectives: Residue levels of dioxin-like compounds (dioxins, furans, mono-ortho PCBs and non-ortho PCBs) expressed in ng of…
Read moreA population PK-PD method for categorical data analysis of progesterone antagonist activity in the rabbit McPhail’s model
Thursday 16 October, 2025
Objectives: The McPhail's test [1] of endometrial differentiation and thickening is a commonly used method for preclinical assessment of progesterone…
Read moreInterspecies Population Modeling Of Pharmacokinetic Data Available At The End Of Drug Discovery
Thursday 16 October, 2025
Objectives: One of the challenges in pharmacokinetics is to predict pharmacokinetic profiles of new chemical entities in the transition from…
Read moreDo we need a perfect basic structural model before exploring the covariate model? Example with enoxaparin
Thursday 16 October, 2025
PDF of presentation Background: Major bleeding complications with low-molecular-weight heparin (LMWH) treatment have been reported from pharmacovigilance, randomised and observational…
Read moreChallenges in modelling the pharmacokinetics of isoniazid in South African tuberculosis patients
Thursday 16 October, 2025
PDF of presentation Objectives: The modelling of isoniazid was part of a larger project investigating the interindividual and interoccasional variability…
Read moreInsulin secretion and hepatic extraction during euglycemic clamp study: modelling of insulin and C-peptide data
Thursday 16 October, 2025
Objectives: Insulin and C-peptide are co-secreted peptides from beta-cells on an equimolar basis. While 40-85% of insulin have been reported…
Read morePopulation pharmacokinetic modeling of total and unbound docetaxel plasma concentrations in cancer patients with poor liver function
Thursday 16 October, 2025
PDF of presentation Objectives: Docetaxel is a chemotherapy agent approved for treatment of breast cancers, non-small cell lung cancers and…
Read moreHow is model building reported for population PK-PD? An exhaustive survey of the literature between 2002 and 2004
Thursday 16 October, 2025
PDF of presentation Purpose: An exhaustive description of data, model, and methodology ensuring confidence in clinical and statistical interpretations, is…
Read moreAre population PK/PD models adequately evaluated? An exhaustive survey of the literature between 2002 and 2004
Thursday 16 October, 2025
PDF of presentation Purpose: Model evaluation is an important issue in population PK and/or PD analyses. The objective of the…
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