Oral presentation: Integration of literature data Archives - PAGE Meeting (Population Approach Group Europe)

Exploring different body-size metric based dosing strategies for propofol in morbidly obese versus healthy weight subjects by modelling and simulation approach

Thursday 16 October, 2025

Objectives: Propofol is an intravenous anaesthetic that is dosed based upon the subject’s body weight. Although effective for subjects of…

A mechanistic model of the steady-state relationship between HbA1c and average glucose levels in a mixed population of healthy volunteers and diabetic subjects

Thursday 16 October, 2025

Background: A mechanism-based model exists that describes the fasting plasma glucose (FPG) and HbA1c relationship[1]. However, a mechanistic description of…

When and how should I combine patient-level data and literature data in a meta-analysis?

Thursday 16 October, 2025

Meta-analysis is an integral part of the model-based drug development paradigm [1]. While meta-analysis of individual patient data (IPD) is…

Meta- Analysis of Retention Rates of Post-Marketing Trials to Compare Effectiveness of Second Generation Antiepileptic Drugs

Thursday 16 October, 2025

Objectives: Retention is the duration of time a patient stays on treatment. It reflects the overall patient experience with the…