Objectives: Children with HIV associated tuberculosis often require coformulated lopinavir/ ritonavir (LPV/RTV)-based antiretroviral treatment with rifampicin-based antitubercular treatment (ATT). Rifampicin…
Read moreObjectives: In this work, we present the analysis of a general mechanism-based PK model for a conjugated mAb-based drug using…
Read moreObjectives: MK-2295 is a potent TRPV1 (transient receptor potential vanilloid subfamily, member 1; also known as VR1) antagonist currently in…
Read moreObjectives: Rituximab has dramatically improved the survival of patients with non-Hodgkin lymphomas (NHL) but currently used dosing regimen should be…
Read moreObjectives: Treatment of schizophrenia has traditionally been focused on antagonizing the central D2-receptor and sufficient central D2 occupancy is a…
Read moreObjectives: Hypertension is a common toxicity for anti-angiogenic drugs targeting the VEGF pathway, such as tyrosine kinase inhibitors (e.g. sorafenib…
Read moreObjectives: Recently, Cohen et al[1] published an original work focusing on the effect of RBC LS heterogenicity on formation of…
Read moreObjectives: Sipoglitazar, a novel orally available PPAR agonist with activities for PPAR α, δ and γ is metabolised through UGT….
Read moreObjectives: Individual drug pharmacokinetics (PK) and treatment adherence are key determinants of HIV sustained virological response. Assessment of adherence performed…
Read moreBackground: Obesity and weight gain, caused by an imbalance between energy intake and energy expenditure, play a primary role in…
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