Oral: Lewis Sheiner

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Oral: Lewis Sheiner

Model-based approach to optimizing antibiotic therapy for central nervous system infections: integrating blood-brain barrier permeability, cerebrospinal fluid hydrodynamics, and site-specific drug exposure

Thursday 7 May, 2026

Objectives: Central nervous system (CNS) infections such as meningitis, ventriculitis, and encephalitis occur across physiologically distinct compartments where antibiotic distribution…

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New methods based on the Fisher Information Matrix for evaluation and optimisation of designs testing relevance of covariates in pharmacometrics

Thursday 7 May, 2026

Objectives One aim of pharmacometrics is to explain inter-individual variability (IIV) through covariate identification [1]. Covariate effects are assessed through…

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Modelling home-measured peak expiratory flow using a mixed-effects hidden Markov model: An alternative approach to quantifying treatment effects in asthma

Thursday 7 May, 2026

Objectives Lung function of people with asthma fluctuates substantially over time, and increased variability has been linked to elevated risk…

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