Thursday 16 October, 2025
Objectives: Chimeric antigen receptor (CAR)-T cell therapy has increased the prognosis of patients with relapsed/refractory Non-Hodgkin lymphoma (NHL) significantly [1–3]….
Read moreOral: Lewis Sheiner Student Session
Mathematically Modelling CD19+ B Cell Reconstitution After Insult to the Immune System: Paediatric Allogeneic Haematopoietic Stem Cell Transplantation, Rituximab Therapy and Epstein-Barr Viral Reactivation
Thursday 16 October, 2025
Introduction: To date, studies of immune recovery after haematopoietic stem cell transplantation (HSCT) have focussed on T cells and adult…
Read moreMachine-Learning for cancer treatment: Guided covariate selection for TTE models developed from real world data with a small number of patients
Thursday 16 October, 2025
Introduction: Bevacizumab slows angiogenesis through inhibition of the vascular endothelial growth factor A (VEGF-A). Indeed, VEGF-A primarily and Intercellular Adhesion…
Read moreModel-based design of innovative treatment strategies to suppress antimicrobial resistance using collateral sensitivity
Thursday 16 October, 2025
Objectives: Antimicrobial resistance (AMR) is a serious threat to public health. To alleviate this threat, innovative treatment strategies using available…
Read moreA semi-mechanistic model of the population pharmacokinetics and bactericidal activity of high-dose isoniazid against multi-drug-resistant tuberculosis
Thursday 16 October, 2025
Objective: The emerging threat of drug-resistant Mycobacterium tuberculosis (M.tb) strain has made it essential to optimise and customise old and…
Read moreHost-Pathogen interactions: A mechanism-based disease progression model to describe the pathogenesis of Acinetobacter baumannii pneumonia
Thursday 16 October, 2025
Objectives: Pneumonia, an acute lower respiratory tract infection, is the fourth most common cause of death globally [1]. Emergence of…
Read moreCause-specific hazard models with markovian elements to quantify the fludarabine exposure-response relationship: from learning to confirming in allogeneic hematopoietic cell transplantation
Thursday 16 October, 2025
Objectives: Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment for a variety of malignant and benign hematological disorders….
Read moreNovel pharmacometric techniques to quantify and prevent iatrogenic withdrawal in children
Thursday 16 October, 2025
Introduction: Prolonged treatment with analgesics and sedatives can cause iatrogenic withdrawal syndrome (IWS) in children being weaned from these drugs…
Read moreA physiologically-based population pharmacokinetic analysis to assess a lower efavirenz dose of 400 mg once daily in HIV-infected pregnant women.
Thursday 16 October, 2025
Background: Globally, efavirenz (EFV) is a cornerstone for the treatment of HIV infection. There is interest in exploring lower EFV…
Read moreDynamic Energy Budget (DEB) based models of tumor-in-host growth inhibition and cachexia onset
Thursday 16 October, 2025
Objectives: The great contribution of PK-PD tumor growth inhibition (TGI) models in the anticancer drug development process is already well-established….
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