Oral: Immunogenicity and Anti-Drug Antibodies Archives - PAGE Meeting (Population Approach Group Europe)

Towards understanding anti-infliximab antibody development to predict Crohn’s disease patients’ underlying immunogenicity status

Thursday 16 October, 2025

Introduction: Inflammatory bowel diseases (IBD), including Crohn’s disease (CD), are a group of auto-immune diseases that affect the gastrointestinal tract….

Immunogenicity dynamics and covariate effects after satralizumab administration predicted with a Hidden Markov Model

Thursday 16 October, 2025

Objectives:Developing a deeper understanding of immunogenicity is important for biologics drug development [1,2]. Immunogenicity is the propensity of a therapeutic…

Learn-and-Confirm in Quantitative Systems Pharmacology: Evaluation of an Immunogenicity Platform

Thursday 16 October, 2025

Introduction: Immunogenicity (IG) against therapeutic proteins often impacts their pharmacokinetics (PK), pharmacodynamics, efficacy and safety. Predicting IG is complex and…