Thursday 16 October, 2025
Background: Joint models of longitudinal process and time to event data have recently gained attention specially for providing individualized dynamic…
Read moreOral: Drug/Disease Modelling
Computational modeling of dynamical liver function tests – Stratification and individualization using standardized models and data
Thursday 16 October, 2025
Objectives: Assessment of liver function is a key task in hepatology but accurate quantification of hepatic function has remained a…
Read moreMechanistic representation of parasite host –dynamics highlights sensitivities of experimental endpoints throughout antimalarial development
Thursday 16 October, 2025
Objectives: In the context of aspired malaria elimination being threatened by emerging resistance against current first-line treatments, health system weaknesses,…
Read moreA system pharmacology approach to tackle the HIV prevention crisis
Thursday 16 October, 2025
Objectives: According to the The Joint United Nations Programme on HIV and AIDS (UNAIDS) estimates, approximately 37.9 million individuals worldwide…
Read moreEnabling pemetrexed treatment in patients with renal dysfunction: time to revise the exposure-toxicity relationship.
Thursday 16 October, 2025
Introduction: Pemetrexed is a widely used cytostatic agent for the treatment of non-small cell lung cancer (NSCLC) and mesothelioma. Dosing…
Read moreDefining preventive targets and dosing recommendations for dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy
Thursday 16 October, 2025
Objectives:Malaria during pregnancy affects 11 million African women each year and, when parasites sequester in the placenta causing placental malaria,…
Read moreDevelopment of a nonparametric Population pharmacokinetic model of tobramycin for Bayesian therapeutic drug monitoring of tobramycin in pediatric patients with cystic fibrosis and dosing simulations.
Thursday 16 October, 2025
Objectives: Children with cystic fibrosis (CF) may benefit from tobramycin therapeutic drug monitoring and pharmacokinetic-based dosage adjustment, which is routine…
Read moreA Pharmacokinetic-Pharmacodynamic model to describe myotoxicity following red-bellied black snake envenomation.
Thursday 16 October, 2025
Introduction: Red-bellied black snake (RBBS; Pseudechis porphyriacus) envenomation can cause systemic myotoxicity with increased serum creatine kinase (CK) concentrations greater…
Read moreA physiologically-based pharmacokinetic model for adeno-associated virus mediated gene therapy targeting the central nervous system
Thursday 16 October, 2025
Introduction: In recent years, adeno-associated viruses (AAV’s) have demonstrated significant progress and promise as vectors for gene therapy. Although the…
Read moreTumor Growth Inhibition (TGI) Modeling with early clinical data to support clinical dose selection in metastatic breast cancer
Thursday 16 October, 2025
Objectives: Tumor Growth Inhibition (TGI) modeling is a model-based approach developed for oncology to assess treatment-induced anti-tumor activity based on…
Read more