Thursday 16 October, 2025
Objectives: We previously developed NLME models to characterize the effect of cladribine tablets on clinical outcomes in patients with relapsing-remitting multiple…
Read moreOral: Clinical Applications
These abstracts are expected to deal with applications of pharmacometrics whose aim is to improve individual patient treatment. They may include studies that have identified covariates that can be applied to calculate the dose, or even better, if the application was able to take patient response (concentration, biomarker) and further improve the individual dose. They can include simulation studies that explore how to improve patient treatment by dose individualization. The abstract must indicate an algorithm demonstrating how an individual patient dose is calculated.
A Semi-mechanistic Model of Lymphocyte Dynamics in Patients with Multiple Sclerosis Treated with Cladribine Tablets
Thursday 16 October, 2025
Objectives: Cladribine tablets therapy has shown substantial effectiveness in multiple sclerosis (MS) [1–3]. Since the drug selectively reduces peripheral lymphocyte…
Read moreModeling of tumor size reduction patterns in advanced melanoma under treatment with MK-3475, a potent antibody against PD-1
Thursday 16 October, 2025
Objectives: Limited information is available on the dynamics of tumor size (TS) in advanced melanoma. In the current analysis a…
Read moreAnnouncement of WCoP 2016
Thursday 16 October, 2025
WCoP 2016 21-24 August, Brisbane, Australia http://wcop2016.org/ On behalf of the WCoP 2016 organizing committee, it is our great pleasure…
Read moreModelling and simulation of neurological endpoints (modified Rankin Scale [mRS] and National Institute of Health Stroke Scale [NIHSS]) to aid clinical trial design in intracerebral hemorrhage (ICH)
Thursday 16 October, 2025
Objective: To develop a modeling and simulation framework for longitudinally observed mRS and NIHSS scores in patients with intracerebral hemorrhage…
Read moreQuantification of the analgesic effect of intranasal coadministration of ketamine and sufentanil in adults to support the development of a pain relief treatment (CT001) in children
Thursday 16 October, 2025
Introduction/Objectives: In the development program for a non-invasive treatment for acute and procedural pain in children, intranasal coadministration of sufentanil…
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