Abstracts - PAGE Meeting (Population Approach Group Europe)

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Abstracts (28)

I-01

Modelling of Dexamethasone in Paediatric Leukaemia Patients using a Population Pharmacokinetic Approach

Wednesday 10:30-12:00

I-29Thu Thuy Nguyen

Population pharmacodynamic model of bronchodilator response to salbutamol in wheezy preschool children

Wednesday 10:30-12:00

I-34Olafuyi Olusola

The Use of Physiologically Based Pharmacokinetic Modelling in Assessing Drug–drug Interactions Associated with Antimalarial Treatment in Paediatrics Co-infected with Tuberculosis: A Case Study with Lumefantrine and Rifampicin.

Wednesday 10:30-12:00

I-37Maria Panselina

Dose-saturable model for amoxicillin used to predict probability of response in normal and obese pediatrics

Wednesday 10:30-12:00

I-58Didier Renard

Label extension for canakinumab in Adult Onset Still’s Disease (AOSD) – Extrapolation from pediatrics to adults

Wednesday 10:30-12:00

I-60Christelle Rodrigues

Population pharmacokinetics of the sustained-release granule formulation of valproic acid in epileptic children

Wednesday 10:30-12:00

I-70Stein Schalkwijk

Placental Transfer of Darunavir and Simulation of Fetal Exposure

Wednesday 10:30-12:00

II-14Giovanni Smania

The role of modelling and simulation in the paediatric investigation plan of a xanthine oxidase inhibitor for tumor lysis syndrome prevention

Wednesday 15:10-16:30

II-27Tjokosela Tikiso

Population Pharmacokinetics of Abacavir in HIV-infected African children

Wednesday 15:10-16:30

II-31Alexios Tsiligiannis

Optimization of a paediatric FDC tablet and dosing regimen for the first line treatment of tuberculosis.

Wednesday 15:10-16:30

II-47Swantje Völler

Normalisation weight in a covariate function affects the relative standard error of clearance: an example with paediatric data

Wednesday 15:10-16:30

II-51Sebastian Weber

Bayesian Pharmacokinetic Extrapolation from Dense Adult to Sparse Pediatric Data

Wednesday 15:10-16:30

II-56Mélanie Wilbaux

Effects of Formula Milk on Weight Changes in Healthy Term and Preterm Neonates

Wednesday 15:10-16:30

III-02Esther Encinas

Application of modelling and simulation (M&S) methods within the context of a paediatric-use marketing authorisation (PUMA) application

Thursday 09:50-11:20

III-08Aline Fuchs

Minimization of a utility function for optimizing the dosing frequency of amoxicillin administration in neonates according to a fixed PK/PD index

Thursday 09:50-11:20

III-09Saskia Fuhrmann

Model-based comparison of mAb clearance in pediatric populations*

Thursday 09:50-11:20

III-18Sungwoo Goo

Population pharmacokinetics(PK)/Pharmacodynamics(PD) modeling and simulation of vancomycin in pediatric infectious patients

Thursday 09:50-11:20

III-19Verena Gotta

Conceptual evaluation of urea rebound in pediatric hemodialysis patients by a physiology-based pharmacokinetic simulation study

Thursday 09:50-11:20

III-30Paul Healy

Impact of metabolic polymorphism on the exposure to tramadol and its active metabolite in children

Thursday 09:50-11:20

III-52Frank Kloprogge

Pharmacodynamics of vancomycin in children

Thursday 09:50-11:20

III-53Ben Kluender

Pharmacokinetic and Exposure-Response Analyses for Extrapolation of Efficacy of Adalimumab in Adolescent Patients with Hidradenitis Suppurativa‎

Thursday 09:50-11:20

III-56Gilbert Koch

Characterization of heart rate and sleeping patterns in pre-term neonates

Thursday 09:50-11:20

III-62

Population pharmacokinetics of Rimeporide: a sodium-hydrogen exchanger (NHE-1) inhibitor for patients with Duchenne Muscular Dystrophy (DMD)

Thursday 09:50-11:20

IV-05Louise Andrews

New population pharmacokinetic model that predicts the individual starting dose of tacrolimus following pediatric renal transplantation

Thursday 14:45-16:15

IV-32Elisa Calvier

Accuracy of plasma clearance scaling from adults to children using pathway-specific covariate models: a systematic investigation using a physiologically-based pharmacokinetic workflow

Thursday 14:45-16:15

IV-36Anne Chain

An Extrapolation Approach to Aprepitant Pediatric Drug Development

Thursday 14:45-16:15

IV-45Palang Chotsiri

Population pharmacokinetic and time-to-event modelling of the antimalarial drug lumefantrine in young children with severe acute malnutrition

Thursday 14:45-16:15

IV-49Sinziana Cristea

The impact of renal transporters on paediatric renal clearance

Thursday 14:45-16:15