Abstracts - PAGE Meeting (Population Approach Group Europe)

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Abstracts (32)

B-03Nigel Klein

A biological perspective on immune response to drug treatment (intended and unintended effects)

Wednesday 09:00-09:40

B-04Hans Peter Grimm

Intricate PK and PD for the novel immunocytokine CEA-IL2v and their pre-clinical to clinical translation

Wednesday 09:40-10:00

B-05Kirill Peskov

Investigation of anti-CTLA-4 immuno-oncology therapy through a quantitative systems pharmacology model

Wednesday 10:00-10:20

B-07Kapil Gadkar

A Six-Stage Workflow for Robust Application of Systems Pharmacology

Wednesday 11:40-12:00

B-08Rob van Wijk

The zebrafish as model for translational systems pharmacology: expanding the allometric scale in vertebrates with five orders of magnitude

Wednesday 12:00-12:20

B-10

Introduction to the Gates’ Healthy Birth, Growth & Development knowledge integration project

Wednesday 13:50-14:05

B-11

Trajectory modelling based on early childhood longitudinal growth data

Wednesday 14:05-14:45

B-12Niclas Jonsson

Determinants for physical growth patterns in low- and middle-income countries

Wednesday 14:45-15:05

B-13Nick Holford

Announcement of WCoP 2016

Wednesday 15:05-15:10

B-15Mélanie Wilbaux

Characterizing and Forecasting Individual Weight Changes in Term Neonates

Wednesday 16:40-17:00

B-16Nick Holford

Growth and decline of body size and composition – Prediction of the transition from pre-diabetes to Type 2 diabetes in humans

Wednesday 17:00-17:20

B-18Tram Nguyen

The paradox of highly effective sofosbuvir combo therapy despite slow viral decline

Wednesday 17:40-18:00

B-19Rik Schoemaker

Extrapolation of a Brivaracetam Exposure-Response Model from Adults to Children

Wednesday 18:00-18:20

C-01Elin Svensson

Bedaquiline’s exposure-response relationship revealed through modeling of mycobacterial load

Thursday 08:45-09:10

C-02Solène Desmée

Joint modelling for nonlinear longitudinal PSA kinetics and survival data in metastatic prostate cancer patients

Thursday 09:10-09:35

C-03Stein Schalkwijk

A physiologically-based population pharmacokinetic analysis to assess a lower efavirenz dose of 400 mg once daily in HIV-infected pregnant women.

Thursday 09:35-10:00

C-06Matts Kågedal

Time-to-Event Modeling of Peripheral Neuropathy – Platform Mega-Analysis of Eight vc-MMAE Antibody-Drug Conjugates (ADCs)

Thursday 11:30-11:50

C-07

Mixed-effect modelling of transient tumour growth dynamics following anti-angiogenic therapy

Thursday 11:50-12:10

C-08Maria Luisa Sardu

Modelling of classified individual tumor lesions in metastatic colorectal cancer (mCRC) patients using delay differential equations.

Thursday 12:10-12:30

C-10Robert Bauer

An overview of Estimation-Maximization Algorithms Used in Population Analysis Methods

Thursday 13:50-14:35

C-11Brian Corrigan

Announcement of ACoP7

Thursday 14:35-14:40

C-13

Adaptive dose finding for time-to-event outcomes with adaptive choice of patient number based on response rate

Thursday 16:00-16:20

C-14Sebastian Wicha

A general pharmacodynamic interaction model based on the Bliss Independence criterion

Thursday 16:20-16:40

C-15Martin Fink

Improving priors for human mAb linear PK parameters by using half-lives from pre-clinical studies

Thursday 16:40-17:00

C-16David McDougall

The Impact of Model Selection for Personalised Dosing

Thursday 17:00-17:20

D-01Lutz Harnisch

Modelling and simulation of neurological endpoints (modified Rankin Scale [mRS] and National Institute of Health Stroke Scale [NIHSS]) to aid clinical trial design in intracerebral hemorrhage (ICH)

Friday 09:00-09:20

D-02Oliver Sander

Model-based development of the secukinumab dosing regimen for the treatment of moderate-to-severe chronic plaque psoriasis

Friday 09:20-09:40

D-03Rasmus Juul Kildemoes

Repeated time to event modelling of opioid consumption in postoperative pain

Friday 09:40-10:00

D-04Thu Thuy Nguyen

Limited sampling strategy for a population pharmacokinetic modelling of cocktail of phenotyping drugs

Friday 10:00-10:20

D-07Sylvie Retout

How disease modeling and model-based meta-analyses contributed to understanding the path forward after dose discontinuation of a Phase III study in Alzheimer’s disease

Friday 11:00-11:20

D-08Marc Vandemeulebroecke

A longitudinal Item Response Theory model to characterize cognition over time in elderly subjects

Friday 11:20-11:40

D-09Simon Buatois

Utilizing the items from the MDS-UPDRS score to increase drug effect detection power in de novo idiopathic Parkinson’s disease patients

Friday 11:40-12:00